Baseline characteristics of 626 patients with newly diagnosed MM
| Characteristic . | n/N (%) . | Median (range) . |
|---|---|---|
| Age at diagnosis, y | 57 (26-83) | |
| Male | 382/626 (61) | |
| ISS stage | ||
| I | 122/626 (19) | |
| II | 236/626 (38) | |
| III | 268/626 (43) | |
| Cytogenetics abnormalities by iFISH | ||
| High risk* | 172/557 (31) | |
| Standard risk† | 385/557 (69) | |
| M-component | ||
| IgG | 307/626 (49) | |
| IgA | 151/626 (24) | |
| Light chain | 119/626 (19) | |
| Other | 49/626 (8) | |
| First-line therapy | ||
| IMiDs‡ | 236/626 (38) | |
| PIs‡ | 401/626 (64) | |
| First-line transplantation§ | 182/626 (29) | |
| Best response to first-line therapy | ||
| CR | 265/626 (42) | |
| VGPR | 161/626 (26) | |
| PR | 133/626 (21) | |
| TBR, mo | 3.1 (0.7-19.0) | |
| DBR, mo | 21.2 (1.5-130.0) |
| Characteristic . | n/N (%) . | Median (range) . |
|---|---|---|
| Age at diagnosis, y | 57 (26-83) | |
| Male | 382/626 (61) | |
| ISS stage | ||
| I | 122/626 (19) | |
| II | 236/626 (38) | |
| III | 268/626 (43) | |
| Cytogenetics abnormalities by iFISH | ||
| High risk* | 172/557 (31) | |
| Standard risk† | 385/557 (69) | |
| M-component | ||
| IgG | 307/626 (49) | |
| IgA | 151/626 (24) | |
| Light chain | 119/626 (19) | |
| Other | 49/626 (8) | |
| First-line therapy | ||
| IMiDs‡ | 236/626 (38) | |
| PIs‡ | 401/626 (64) | |
| First-line transplantation§ | 182/626 (29) | |
| Best response to first-line therapy | ||
| CR | 265/626 (42) | |
| VGPR | 161/626 (26) | |
| PR | 133/626 (21) | |
| TBR, mo | 3.1 (0.7-19.0) | |
| DBR, mo | 21.2 (1.5-130.0) |
iFISH, interphase fluorescent in situ hybridization.
High-risk cytogenetic abnormalities (CAs) were defined as the presence of 20% or more del(17p) or 10% or more t(4;14), t(14;16), or t(14;20) in screened plasma cells.
Standard-risk CAs defined by the absence of high-risk CAs.
A total of 11 patients who received IMiDs combined with PIs were counted twice.
First-line transplantation was defined as transplantation within 12 months of first-line therapy.