Standard first-line therapy for ITP
| Therapy and dose . | Dose . | Time to response . | Prominent side effects . |
|---|---|---|---|
| Corticosteroids | 3-4 d | Mood changes, hypertension, hyperglycemia, gastritis | |
| Adults | Prednisone 1-2 mg/kg per day with taper | ||
| Dexamethasone 40 mg/d × 4 days for 1-3 cycles | |||
| Children | 2-4 mg/kg orally divided two times a day for 5-7 days | ||
| IVIg | 0.8-1.0 g/kg IV for one dose | 24-48 h | Infusion reaction, headache, aseptic meningitis, thrombosis |
| Anti-D immunoglobulin | 50-75 µg/kg IV for one dose | 24-48 h | Hemolysis (2.0 g decrease in hemoglobin), FDA black box warning |
| Therapy and dose . | Dose . | Time to response . | Prominent side effects . |
|---|---|---|---|
| Corticosteroids | 3-4 d | Mood changes, hypertension, hyperglycemia, gastritis | |
| Adults | Prednisone 1-2 mg/kg per day with taper | ||
| Dexamethasone 40 mg/d × 4 days for 1-3 cycles | |||
| Children | 2-4 mg/kg orally divided two times a day for 5-7 days | ||
| IVIg | 0.8-1.0 g/kg IV for one dose | 24-48 h | Infusion reaction, headache, aseptic meningitis, thrombosis |
| Anti-D immunoglobulin | 50-75 µg/kg IV for one dose | 24-48 h | Hemolysis (2.0 g decrease in hemoglobin), FDA black box warning |