Table 3.

Results that “rule-in” or “rule-out” leg DVT

Results
Rules-in a first leg DVT 
Venous ultrasound 
 Noncompressibility of proximal veins (calf vein trifurcation included) 
 Noncompressibility of distal veins, when findings are extensive 
 Intraluminal defect (unequivocal) with associated absence of flow in the iliac veins or inferior vena cava, when compressibility cannot be assessed 
Venography 
 Intraluminal filling defect in proximal or distal deep veins 
Rules-out a first leg DVT 
D-dimer 
 Negative very sensitive test (eg, D-dimer <500 μg/L) AND low or moderate CPTP 
 Negative moderately sensitive test (including D-dimer <1000 μg/L) AND low CPTP 
Venous ultrasound 
 Fully compressible proximal veins AND low CPTP 
 Fully compressible proximal veins AND moderately or very sensitive D-dimer test 
 Fully compressible proximal and distal veins (whole-leg US) 
 Fully compressible proximal veins AND normal repeat proximal US after 7 d 
Venography 
 All deep veins seen and no intraluminal filling defects 
Rules-in a recurrent leg DVT 
Venous ultrasound 
 A new, noncompressible proximal vein segment 
 A 4-mm increase in diameter of the common femoral or popliteal vein compared with a previous test 
 A unequivocal extension of thrombosis (eg, additional 10 cm) within the femoral vein 
Venography 
 Intraluminal filling defect in proximal or distal deep veins (new, or >3 mo after last event) 
Rules-out a recurrent leg DVT 
All criteria that rule-out a first DVT 
Venous ultrasound 
 ≤1 mm increase in diameter of the common femoral, and femoral and popliteal veins compared with a previous test AND remains unchanged on repeat testing after 2 d and 7 d 
Results
Rules-in a first leg DVT 
Venous ultrasound 
 Noncompressibility of proximal veins (calf vein trifurcation included) 
 Noncompressibility of distal veins, when findings are extensive 
 Intraluminal defect (unequivocal) with associated absence of flow in the iliac veins or inferior vena cava, when compressibility cannot be assessed 
Venography 
 Intraluminal filling defect in proximal or distal deep veins 
Rules-out a first leg DVT 
D-dimer 
 Negative very sensitive test (eg, D-dimer <500 μg/L) AND low or moderate CPTP 
 Negative moderately sensitive test (including D-dimer <1000 μg/L) AND low CPTP 
Venous ultrasound 
 Fully compressible proximal veins AND low CPTP 
 Fully compressible proximal veins AND moderately or very sensitive D-dimer test 
 Fully compressible proximal and distal veins (whole-leg US) 
 Fully compressible proximal veins AND normal repeat proximal US after 7 d 
Venography 
 All deep veins seen and no intraluminal filling defects 
Rules-in a recurrent leg DVT 
Venous ultrasound 
 A new, noncompressible proximal vein segment 
 A 4-mm increase in diameter of the common femoral or popliteal vein compared with a previous test 
 A unequivocal extension of thrombosis (eg, additional 10 cm) within the femoral vein 
Venography 
 Intraluminal filling defect in proximal or distal deep veins (new, or >3 mo after last event) 
Rules-out a recurrent leg DVT 
All criteria that rule-out a first DVT 
Venous ultrasound 
 ≤1 mm increase in diameter of the common femoral, and femoral and popliteal veins compared with a previous test AND remains unchanged on repeat testing after 2 d and 7 d 
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