Table 1.

University of Iowa enoxaparin prophylaxis dosing guidelines for adult patients

IndicationNonobese (BMI <30 kg/m2)Obese (BMI 30 to 39 kg/m2)Morbidly obese (BMI ≥40 kg/m2)
Dose (mg)Dose frequencyDose (mg)Dose frequencyDose (mg)Dose frequency
Medical patients       
Acute medical 40 Once per day 30 or 40 Once every 12 h 30 or 40 Once every 12 h 
Medical ICU 30 Once every 12 h 30 or 40 Once every 12 h 30 or 40 Once every 12 h 
Trauma or surgical patients       
Moderate risk 40 Once per day 30 or 40 Once every 12 h 30 or 40 Once every 12 h 
 Laparoscopic, vascular, or minor surgery       
 General surgery       
 Gynecologic surgery       
 Urologic surgery       
 Burn injury       
High risk 30 or 40 Once every 12 h 30 or 40 Once every 12 h 40 or 60 Once every 12 h 
 General surgery with risk factors*       
 Burn injury with risk factors†       
 Cancer surgery       
 Spinal cord injury       
 Bariatric surgery       
 Major trauma       
Orthopedic surgical patients       
Hip replacement 30 Once every 12 h 30 or 40 Once every 12 h 40 or 60 Once every 12 h 
Knee replacement       
Hip fracture surgery       
IndicationNonobese (BMI <30 kg/m2)Obese (BMI 30 to 39 kg/m2)Morbidly obese (BMI ≥40 kg/m2)
Dose (mg)Dose frequencyDose (mg)Dose frequencyDose (mg)Dose frequency
Medical patients       
Acute medical 40 Once per day 30 or 40 Once every 12 h 30 or 40 Once every 12 h 
Medical ICU 30 Once every 12 h 30 or 40 Once every 12 h 30 or 40 Once every 12 h 
Trauma or surgical patients       
Moderate risk 40 Once per day 30 or 40 Once every 12 h 30 or 40 Once every 12 h 
 Laparoscopic, vascular, or minor surgery       
 General surgery       
 Gynecologic surgery       
 Urologic surgery       
 Burn injury       
High risk 30 or 40 Once every 12 h 30 or 40 Once every 12 h 40 or 60 Once every 12 h 
 General surgery with risk factors*       
 Burn injury with risk factors†       
 Cancer surgery       
 Spinal cord injury       
 Bariatric surgery       
 Major trauma       
Orthopedic surgical patients       
Hip replacement 30 Once every 12 h 30 or 40 Once every 12 h 40 or 60 Once every 12 h 
Knee replacement       
Hip fracture surgery       

ICU, intensive care unit.

*

Risk factors include cancer, previous venous thromboembolism, duration of surgery >3 h, and age >60 y.

†

Risk factors include extensive lower extremity burns, concomitant lower extremity trauma, use of a femoral vein catheter, and age >60 y.

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