Table 2.

Practical ABCDE steps to reduce CV disease in patients with CML receiving TKI treatment

ABCDE prevention stepsActions/measures
Awareness of CV disease signs and symptoms 
Aspirin in select patients 
Ankle–brachial index measurement to monitor for peripheral artery disease 
Blood pressure control 
Cigarette and tobacco cessation 
Cholesterol level, including regular monitoring and treatment, if needed 
Diabetes mellitus regular monitoring and treatment, if needed 
Diet and weight management 
Exercise 
ABCDE prevention stepsActions/measures
Awareness of CV disease signs and symptoms 
Aspirin in select patients 
Ankle–brachial index measurement to monitor for peripheral artery disease 
Blood pressure control 
Cigarette and tobacco cessation 
Cholesterol level, including regular monitoring and treatment, if needed 
Diabetes mellitus regular monitoring and treatment, if needed 
Diet and weight management 
Exercise 

CML, chronic myeloid leukemia; CV, cardiovascular; TKI, tyrosine kinase inhibitor.

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