Table 2. Time points of evaluation of... | American Society of Hematology

Table 2.

Time points of evaluation of prognostic factors (other than Rai/Binet stage and age)

	Initial diagnosis asymptomatic	Initial diagnosis symptomatic	Before start frontline therapy	Before start* relapse therapy
del(17p)/TP53 mutation	Yes†	Yes†	Yes‡	Yes‡
del(11q)	No	Yes†	Yes§	Yes§
IGHV	Yes†	Yes*	Yes*	—
Karyotype	No	Yes†	Yes¶	Yes¶
β₂-microglobulin	Yes†	Yes	Yes	—

	Initial diagnosis asymptomatic	Initial diagnosis symptomatic	Before start frontline therapy	Before start* relapse therapy
del(17p)/TP53 mutation	Yes†	Yes†	Yes‡	Yes‡
del(11q)	No	Yes†	Yes§	Yes§
IGHV	Yes†	Yes*	Yes*	—
Karyotype	No	Yes†	Yes¶	Yes¶
β₂-microglobulin	Yes†	Yes	Yes	—

If not done before.

If consequences (more/less intensive follow-up or early treatment; eg, within clinical studies) can be drawn.

Unless TP53 mutation/deletion was already detected before.

If patient would be suitable for FCR.

If patient can be considered for allogeneic transplantation or clinical study.