Summary of known genomic and mutational data in aggressive B-cell lymphomas
| Category . | Associated genotype . | Most frequent mutations . | |
|---|---|---|---|
| GCB-DLBCL | BCL2 or MYC translocations, DH or TH, complex karyotype, PTEN deletion | EZH2, GNA13, BCL6, TNFSR14, FOXO1, ACTB, SOCS1, BCL2, SGK1 | KMT2D, CREBBP, EP300, TP53, HST1H1E/C, B2M |
| ABC-DLBCL | BCL2 amplifications, CDKN2A/B deletion, complex karyotype, rare DH or TH | MYD88, CD79A/B, CARD11, TNFAIP3, PIM1, NOTCH1, SPIB, PRDM1 (mutually exclusive with BCL6 rearrangements) | MHC class I, TP53, MEF2B, NOTCH 2, BTG1/2, SOCS1, DTX, SPEN, TNFAIP3, TMSB4X |
| UNC-DLBCL | Complex karyotype, NOTCH2 amplification, BCL6 translocations, rare MYC with BCL6 DH | NOTCH2 | |
| HG-DH/TH | DH or TH of MYC and BCL2 and/or BCL6 | ||
| HGBL, NOS | No DH nor TH | ||
| BL | MYC rearrangement, 1q gains, no DH or TH, low complexity karyotype | TCF3, ID3 | |
| BLL with 11q alteration | 11q alterations, no MYC rearrangement, no 1q gains | ||
| Category . | Associated genotype . | Most frequent mutations . | |
|---|---|---|---|
| GCB-DLBCL | BCL2 or MYC translocations, DH or TH, complex karyotype, PTEN deletion | EZH2, GNA13, BCL6, TNFSR14, FOXO1, ACTB, SOCS1, BCL2, SGK1 | KMT2D, CREBBP, EP300, TP53, HST1H1E/C, B2M |
| ABC-DLBCL | BCL2 amplifications, CDKN2A/B deletion, complex karyotype, rare DH or TH | MYD88, CD79A/B, CARD11, TNFAIP3, PIM1, NOTCH1, SPIB, PRDM1 (mutually exclusive with BCL6 rearrangements) | MHC class I, TP53, MEF2B, NOTCH 2, BTG1/2, SOCS1, DTX, SPEN, TNFAIP3, TMSB4X |
| UNC-DLBCL | Complex karyotype, NOTCH2 amplification, BCL6 translocations, rare MYC with BCL6 DH | NOTCH2 | |
| HG-DH/TH | DH or TH of MYC and BCL2 and/or BCL6 | ||
| HGBL, NOS | No DH nor TH | ||
| BL | MYC rearrangement, 1q gains, no DH or TH, low complexity karyotype | TCF3, ID3 | |
| BLL with 11q alteration | 11q alterations, no MYC rearrangement, no 1q gains | ||