Table 2.

Genes differentially expressed in CD34+ cells from patients with low-risk MDS compared with healthy controls

GeneAccessionMapDescription-fold
Down-regulation     
 ANXA2 D00017 15q21 Annexin A2 >10  
 BENE U17077 2q13 T-lymphocyte maturation factor >10  
 BTUB X79535 6p21.3 Beta tubulin >10 
 CAPN4 X04106 19 Calpain 5 
 CARD2 X74929 12q13 Keratin 8 8 
 CCND1 M73554 11q13 Cyclin D1 >10 
 CDK2AP1 AF089814 11q13 CDK2-associated protein 10 
 H4M AL021807 6p21.3 H4 histone family >10 
 HRAS1 J00277 11p15.5 H-RAS 1 6 
 HSP70 L12723 5q31 Heat shock protein 70 5 
 IEX1 S81914 6p21.3 Radiation-inducible immediate-early response gene 7  
 ILF3 U10324 19 Interleukin enhancer binding factor 3 >10  
 MAGE3 U03735 Xq28 Melanoma antigen 3 7  
 MAGE4 U10688 Xq28 Melanoma antigen 4 >10  
 MAGE6 U10691 Xq28 Melanoma antigen 6 6 
 MIG2 Z24725 14 Mitogen-inducible gene 6 
 MKPL AF038844 17q12 MKP1-like protein tyrosine phosphatase 6  
 NIN1P D38047 19 Proteasome 26S subunit 31 5  
 OCT3 Z11898 6p21 Octamer-binding protein 3A 6 
 P63 X69910 12 Tumor protein 63 8 
 PDF AB000584 19p Prostate-derived factor >10 
 PSMD11 AB003102 17 Proteasome 26S subunit p44.5 5 
 PSMD13 AB009398 11p15.5 Proteasome 26S subunit p40.5 10  
 RAI3 AF095448 12p13 Retinoic acid-induced gene 8  
 STIP1 M86752 11q13 Stress-induced phosphoprotein 1 >10 
 STRAT X57348 1p Stratifin >10 
 TFAP2 U85658 20q13.2 Transcription factor AP-2 8 
 TM4SF1 AF065388 1 Transmembrane 4 superfamily 1 5 
 TXNR X91247 12q23 Thioredoxin reductase 1 6 
 UBC12 AF075599 19 Ubiquitin-conjugating enzyme 12 >10 
Up-regulation     
 AML1 D43968 21q22.3 Acute myeloid leukemia 1 8  
 ATF3 L19871 1 Activating transcription factor 3 8 
 CDKI1A U03106 6p21.2 Cyclin-dependent kinase inhibitor 1A (p21) >10  
 COIL U06632 17q22-q23 Coilin 7 
 DLEC1 AB020522 3p22 Deleted in lung and esophageal cancer 7  
 DLK1 U15979 14q32 Delta-like homolog 1 7 
 DNM2 L36983 19 Dynamin 8 
 EBAF AF081507 1q42.1 Endometrial bleeding-associated factor 6 
 GNA15 M63904 19p13.3 Guanine-nucleotide-binding protein alpha 15 5  
 HOX7 M97676 4p16 Homeobox 7 6 
 IL-1RAP AB006537 3q28 Interleukin-1 receptor accessory protein >10  
 LTK D16105 15q15.1 Leukocyte tyrosine kinase 5  
 MEOX1 U10492 17q21 Mesenchyme homeobox 1 6  
 PKCB X06318 16p11.2 Protein kinase C, beta 1 6 
 PTPN7 M64322 1q32.1 Protein tyrosine phosphatase nonreceptor type 7 5  
 PTPRS U35234 19p13.3 Protein tyrosine phosphatase receptor S >10 
 SCYA18 Y13710 17q11.2 Small inducible cytokine subfamily A18 6  
 TBR1 U49250 2q23-q37 T-box gene (transcription factor) 6  
 TOB2 D64109 22q13 Transducer of ERB B2 6 
 TRAF6 U78798 11 TNF receptor-associated factor 6 >10 
 ZNF136 U09367 19p13 Zinc finger protein 136 7 
 ZNF261 X95808 Xq13.1 Zinc finger protein 261 >10 
GeneAccessionMapDescription-fold
Down-regulation     
 ANXA2 D00017 15q21 Annexin A2 >10  
 BENE U17077 2q13 T-lymphocyte maturation factor >10  
 BTUB X79535 6p21.3 Beta tubulin >10 
 CAPN4 X04106 19 Calpain 5 
 CARD2 X74929 12q13 Keratin 8 8 
 CCND1 M73554 11q13 Cyclin D1 >10 
 CDK2AP1 AF089814 11q13 CDK2-associated protein 10 
 H4M AL021807 6p21.3 H4 histone family >10 
 HRAS1 J00277 11p15.5 H-RAS 1 6 
 HSP70 L12723 5q31 Heat shock protein 70 5 
 IEX1 S81914 6p21.3 Radiation-inducible immediate-early response gene 7  
 ILF3 U10324 19 Interleukin enhancer binding factor 3 >10  
 MAGE3 U03735 Xq28 Melanoma antigen 3 7  
 MAGE4 U10688 Xq28 Melanoma antigen 4 >10  
 MAGE6 U10691 Xq28 Melanoma antigen 6 6 
 MIG2 Z24725 14 Mitogen-inducible gene 6 
 MKPL AF038844 17q12 MKP1-like protein tyrosine phosphatase 6  
 NIN1P D38047 19 Proteasome 26S subunit 31 5  
 OCT3 Z11898 6p21 Octamer-binding protein 3A 6 
 P63 X69910 12 Tumor protein 63 8 
 PDF AB000584 19p Prostate-derived factor >10 
 PSMD11 AB003102 17 Proteasome 26S subunit p44.5 5 
 PSMD13 AB009398 11p15.5 Proteasome 26S subunit p40.5 10  
 RAI3 AF095448 12p13 Retinoic acid-induced gene 8  
 STIP1 M86752 11q13 Stress-induced phosphoprotein 1 >10 
 STRAT X57348 1p Stratifin >10 
 TFAP2 U85658 20q13.2 Transcription factor AP-2 8 
 TM4SF1 AF065388 1 Transmembrane 4 superfamily 1 5 
 TXNR X91247 12q23 Thioredoxin reductase 1 6 
 UBC12 AF075599 19 Ubiquitin-conjugating enzyme 12 >10 
Up-regulation     
 AML1 D43968 21q22.3 Acute myeloid leukemia 1 8  
 ATF3 L19871 1 Activating transcription factor 3 8 
 CDKI1A U03106 6p21.2 Cyclin-dependent kinase inhibitor 1A (p21) >10  
 COIL U06632 17q22-q23 Coilin 7 
 DLEC1 AB020522 3p22 Deleted in lung and esophageal cancer 7  
 DLK1 U15979 14q32 Delta-like homolog 1 7 
 DNM2 L36983 19 Dynamin 8 
 EBAF AF081507 1q42.1 Endometrial bleeding-associated factor 6 
 GNA15 M63904 19p13.3 Guanine-nucleotide-binding protein alpha 15 5  
 HOX7 M97676 4p16 Homeobox 7 6 
 IL-1RAP AB006537 3q28 Interleukin-1 receptor accessory protein >10  
 LTK D16105 15q15.1 Leukocyte tyrosine kinase 5  
 MEOX1 U10492 17q21 Mesenchyme homeobox 1 6  
 PKCB X06318 16p11.2 Protein kinase C, beta 1 6 
 PTPN7 M64322 1q32.1 Protein tyrosine phosphatase nonreceptor type 7 5  
 PTPRS U35234 19p13.3 Protein tyrosine phosphatase receptor S >10 
 SCYA18 Y13710 17q11.2 Small inducible cytokine subfamily A18 6  
 TBR1 U49250 2q23-q37 T-box gene (transcription factor) 6  
 TOB2 D64109 22q13 Transducer of ERB B2 6 
 TRAF6 U78798 11 TNF receptor-associated factor 6 >10 
 ZNF136 U09367 19p13 Zinc finger protein 136 7 
 ZNF261 X95808 Xq13.1 Zinc finger protein 261 >10 

These genes were selected because a greater than 5-fold difference in expression occurred between CD34+ cells from patients with low-risk MDS and healthy controls.

Accession indicates GenBank accession number; -fold, mean fold change.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal