Table 5.

Genes selected by class membership prediction analysis to be predictive in the distinction between control, low-risk MDS, and high-risk MDS groups

GeneAccessionMapDescription
TACSTD2 J04152 1p32 Tumor-associated calcium signal transducer 2 
UQCRC1 L16842 3p21.3 Ubiquinol-cytochrome C reductase core protein 1  
TNNC1 M37984 3p21.3 Troponin C, slow 
KDELR M88458 7p Endoplasmic reticulum protein retention receptor  
CLC L01664 19q13.1 Charcot-Leyden crystal 
H-PLK M55422 Krueppel-related zinc finger protein 
RGS19 X91809 — Regulator of G-protein signaling 19  
ATF3 L19871 Activating transcription factor 3 
FARP1 AI701049 — FERM, RhoGEF, and pleckstrin domain protein 1 
GNG7 AW051450 — Guanine nucleotide-binding protein gamma 7 
TPD52L2 U44429 6q22-q23 Tumor protein D52-like 2 
GeneAccessionMapDescription
TACSTD2 J04152 1p32 Tumor-associated calcium signal transducer 2 
UQCRC1 L16842 3p21.3 Ubiquinol-cytochrome C reductase core protein 1  
TNNC1 M37984 3p21.3 Troponin C, slow 
KDELR M88458 7p Endoplasmic reticulum protein retention receptor  
CLC L01664 19q13.1 Charcot-Leyden crystal 
H-PLK M55422 Krueppel-related zinc finger protein 
RGS19 X91809 — Regulator of G-protein signaling 19  
ATF3 L19871 Activating transcription factor 3 
FARP1 AI701049 — FERM, RhoGEF, and pleckstrin domain protein 1 
GNG7 AW051450 — Guanine nucleotide-binding protein gamma 7 
TPD52L2 U44429 6q22-q23 Tumor protein D52-like 2 

Samples from patients with high-risk and low-risk MDS and from healthy controls could be correctly classified by examining the CD34+ marrow cells for gene expression profile of these 11 genes by class membership prediction.

Accession indicates GenBank accession number.

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