VWF concentrates in use for the treatment of VWD
| Product . | Manufacturer . | Source of plasma . | Viral inactivation . | VWF:RCo/FVIII ratio . |
|---|---|---|---|---|
| Licensed in both US and Europe | ||||
| Alphanate (USA) | Grifols, USA | USA | SD and dry heat (80°C for 72 h) | 0.91 ± 0.2 |
| Fandhi (Europe) | Grifols, Spain | USA, Slovakia, Spain, Czech Republic | 1.04 ± 0.1 | |
| Humate P (USA) | CSL Behring, Germany | USA | Pasteurization (60°C for 10 h) | 2.45 ± 0.3 |
| Haemate P (Europe) | USA | |||
| Wilate | Octapharma, Austria | USA, Sweden, Austria, Germany | SD and dry heat (100°C for 2 h) | 0.9 |
| Licensed elsewhere | ||||
| Wilfactin | LFB, France | Germany, France, Switzerland | SD and dry heat (80°C for 72 h) | 50 |
| Nanofiltration (35 nM) | ||||
| Immunate | Baxalta, Austria | USA, Austria, Germany, Sweden, Czech Republic | SD and vapor heat (60°C for 10 h) at 190 mbar | 1.1 |
| Factor 8Y | BioProducts Laboratory, England | USA | Dry heat (80°C for 72 h) | 0.81 |
| Biostate (Australia/Asia) | CSL Bioplasma, Australia | USA, Australia, New Zealand, Malaysia, Singapore, Hong Kong USA | SD and dry heat (80°C for 72 h) | 2 |
| Voncento (Europe) | 2.4 | |||
| VONVENDI | Baxalta, USA | N/A - Recombinant | N/A | N/A |
| Product . | Manufacturer . | Source of plasma . | Viral inactivation . | VWF:RCo/FVIII ratio . |
|---|---|---|---|---|
| Licensed in both US and Europe | ||||
| Alphanate (USA) | Grifols, USA | USA | SD and dry heat (80°C for 72 h) | 0.91 ± 0.2 |
| Fandhi (Europe) | Grifols, Spain | USA, Slovakia, Spain, Czech Republic | 1.04 ± 0.1 | |
| Humate P (USA) | CSL Behring, Germany | USA | Pasteurization (60°C for 10 h) | 2.45 ± 0.3 |
| Haemate P (Europe) | USA | |||
| Wilate | Octapharma, Austria | USA, Sweden, Austria, Germany | SD and dry heat (100°C for 2 h) | 0.9 |
| Licensed elsewhere | ||||
| Wilfactin | LFB, France | Germany, France, Switzerland | SD and dry heat (80°C for 72 h) | 50 |
| Nanofiltration (35 nM) | ||||
| Immunate | Baxalta, Austria | USA, Austria, Germany, Sweden, Czech Republic | SD and vapor heat (60°C for 10 h) at 190 mbar | 1.1 |
| Factor 8Y | BioProducts Laboratory, England | USA | Dry heat (80°C for 72 h) | 0.81 |
| Biostate (Australia/Asia) | CSL Bioplasma, Australia | USA, Australia, New Zealand, Malaysia, Singapore, Hong Kong USA | SD and dry heat (80°C for 72 h) | 2 |
| Voncento (Europe) | 2.4 | |||
| VONVENDI | Baxalta, USA | N/A - Recombinant | N/A | N/A |
SD, solvent detergent.