Characteristics of LAD subgroups
| Section 1.01 . | LAD I . | LAD II . | LAD III . |
|---|---|---|---|
| Skin infection | ++ | + | ++ |
| Severe infections | +++ | + | +++ |
| Periodontitis | ++ | ++ | ? |
| Delayed umbilical cord separation | +++ | + | |
| Developmental abnormalities | +++ | ||
| Bleeding tendencies | +++ | ||
| Neutrophilia : baseline | + | +++ | ++ |
| Neutrophilia : with infection | +++ | +++ | +++ |
| Genetic defect | CD18 subunit of β2 integrins (ITGB2) | Fucosylation of selectin ligands (eg, SLeX) because of deficiency in a fucose transporter (SLC35C1) | Inside-out signaling involving kindlin-3 for activation of blood cell β integrins (FERMT3) |
| Section 1.01 . | LAD I . | LAD II . | LAD III . |
|---|---|---|---|
| Skin infection | ++ | + | ++ |
| Severe infections | +++ | + | +++ |
| Periodontitis | ++ | ++ | ? |
| Delayed umbilical cord separation | +++ | + | |
| Developmental abnormalities | +++ | ||
| Bleeding tendencies | +++ | ||
| Neutrophilia : baseline | + | +++ | ++ |
| Neutrophilia : with infection | +++ | +++ | +++ |
| Genetic defect | CD18 subunit of β2 integrins (ITGB2) | Fucosylation of selectin ligands (eg, SLeX) because of deficiency in a fucose transporter (SLC35C1) | Inside-out signaling involving kindlin-3 for activation of blood cell β integrins (FERMT3) |