Table 1. Presenting clinical and... | American Society of Hematology

Table 1.

Presenting clinical and laboratory characteristics of patients with cHD

	BCL-2 expression				P^*
	Known		Unknown
	No.	%	No.	%
All patients	707	100	988	100
Age, y
Median	31	NA	30	NA	.8^†
Range	4-88	NA	5-82	NA
Male sex	383	54	540	55	.8
B symptoms	258/707	36	362/985	37	.9
Histology
Nodular sclerosis	551	78	680	69
Mixed cellularity	143	20	239	24
Lymphocyte depletion	5	1	15	2
Lymphocyte-rich cHD	0	0	3	0.3
cHD not further classified	8	1	51	5
Ann Arbor stage					.6^‡
I	94	13	156	16
II	358	51	482	49
III	142	20	196	20
IV	113	16	154	16
High serum LDH level	213/627	34	204/650	31	.3
High serum β₂-microglobulin level	161/434	37	148/483	31	.04
Bone marrow involvement	55/707	8	55/983	6	.09
Inguinal or iliac node involvement	131/705	19	165/966	17	.4
Mediastinal mass ratio at least 0.45	77/502	15	70/434	16	.8
Low serum albumin level	96/648	15	141/782	18	.1
Anemia	313/702	45	469/968	48	.1
Leukocytosis	67/702	10	116/963	12	.1
Lymphocytopenia	181/637	28	216/863	25	.2

	BCL-2 expression				P^*
	Known		Unknown
	No.	%	No.	%
All patients	707	100	988	100
Age, y
Median	31	NA	30	NA	.8^†
Range	4-88	NA	5-82	NA
Male sex	383	54	540	55	.8
B symptoms	258/707	36	362/985	37	.9
Histology
Nodular sclerosis	551	78	680	69
Mixed cellularity	143	20	239	24
Lymphocyte depletion	5	1	15	2
Lymphocyte-rich cHD	0	0	3	0.3
cHD not further classified	8	1	51	5
Ann Arbor stage					.6^‡
I	94	13	156	16
II	358	51	482	49
III	142	20	196	20
IV	113	16	154	16
High serum LDH level	213/627	34	204/650	31	.3
High serum β₂-microglobulin level	161/434	37	148/483	31	.04
Bone marrow involvement	55/707	8	55/983	6	.09
Inguinal or iliac node involvement	131/705	19	165/966	17	.4
Mediastinal mass ratio at least 0.45	77/502	15	70/434	16	.8
Low serum albumin level	96/648	15	141/782	18	.1
Anemia	313/702	45	469/968	48	.1
Leukocytosis	67/702	10	116/963	12	.1
Lymphocytopenia	181/637	28	216/863	25	.2

NA indicates not applicable.

Fisher exact test was used for all comparisons except for mean age and Ann Arbor stage.

Mean age was evaluated by Mann-Whiney test.

Ann Arbor stage was evaluated by χ² test.