HRs for TRM and RI depending on time interval
| Risk factor . | TRM . | RI . | TRM . | RI . | ||
|---|---|---|---|---|---|---|
| direction . | HR . | CI . | HR . | CI . | ||
| From transplantation until d 100 | ||||||
| aGvHD | ||||||
| Grade 0 (reference) | (1) | (1) | ||||
| Grade I | ↓ 5-153 | ↓5-152 | 0.58 | (0.44-0.76) | 0.47 | (0.18-1.19) |
| Grade II | ↓ 5-153 | ↓5-152 | 0.76 | (0.53-0.38) | 0.44 | (0.16-1.21) |
| Grade III | ↑ 5-151 | ↓ 5-152 | 2.09 | (1.6-2.7) | 0.53 | (0.12-2.32) |
| Grade IV | ↑ 5-151 | ↑5-150 | 6.55 | (5.3-8.1) | 1.31 | (0.38-4.54) |
| Age, per year | ↑ 5-151 | ↑ 5-150 | 1.02 | (1.01-1.03) | 1.00 | (0.97-1.04) |
| Sex, female vs male | ↓ 5-152 | ↑5-151 | 0.99 | (0.82-1.19) | 7.02 | (1.62-30.4) |
| Mismatch, female donor + male recipient versus rest | ↓ 5-152 | ↑5-151 | 0.97 | (0.79-1.19) | 8.73 | (1.97-38.8) |
| Calendar year, per year | ↓ 5-153 | ↑5-150 | 0.93 | (0.91-0.95) | 1.04 | (0.96-1.12) |
| Interval between diagnosis and transplantation, shorter than 12 mo versus 12 mo or longer | ↑ 5-151 | ↑ 5-150 | 1.4 | (1.2-1.7) | 1.30 | (0.64-2.64) |
| From d 100 until 3 y | ||||||
| aGvHD | ||||||
| Grade 0 (reference) | (1) | (1) | ||||
| Grade I | ↑ 5-151 | ↓ 5-153 | 1.52 | (1.19-1.96) | 0.94 | (0.76-1.16) |
| Grade II | ↑ 5-151 | ↓5-153 | 2.48 | (1.95-3.14) | 0.60 | (0.46-0.77) |
| Grade III | ↑ 5-151 | ↓ 5-153 | 5.76 | (4.44-7.48) | 0.48 | (0.29-0.81) |
| Grade IV | ↑ 5-151 | ↓5-153 | 14.7 | (10.9-19.9) | 0.14 | (0.02-0.99) |
| Age, per year | ↑ 5-151 | ↑ 5-151 | 1.03 | (1.02-1.04) | 1.01 | (1.00-1.02) |
| Sex, female versus male | ↑ 5-150 | ↓5-152 | 1.01 | (0.83-1.23) | 0.85 | (0.69-1.05) |
| Mismatch, female donor + male recipient versus rest | ↑ 5-151 | ↓5-152 | 1.36 | (1.11-1.66) | 0.98 | (0.77-1.25) |
| Calendar year, per year | ↓ 5-152 | ↓5-153 | 0.98 | (0.97-1.00) | 0.98 | (0.96-1.00) |
| Interval between diagnosis and transplantation, longer than 12 mo versus 12 mo or longer | ↑ 5-150 | ↑ 5-150 | 1.07 | (0.91-1.26) | 1.00 | (0.83-1.21) |
| From 3 y until 15 y | ||||||
| aGvHD | ||||||
| Grade 0 (reference) | (1) | (1) | ||||
| Grade I | ↓ 5-152 | ↑ 5-150 | 0.75 | (0.35-1.59) | 1.07 | (0.74-1.54) |
| Grade II | ↑ 5-150 | ↑5-150 | 1.03 | (0.52-2.06) | 1.05 | (0.68-1.61) |
| Grades III-IV | ↑ 5-151 | ↓5-152 | 2.94 | (1.45-5.95) | 0.34 | (0.11-1.09) |
| Age, per year | ↑ 5-151 | ↑ 5-150 | 1.04 | (1.01-1.07) | 1.01 | (0.99-1.03) |
| Sex, female versus male | ↓ 5-152 | ↓5-152 | 0.70 | (0.36-1.36) | 0.96 | (0.69-1.35) |
| Mismatch, female donor + male recipient versus rest | ↑ 5-150 | ↓5-153 | 1.72 | (0.93-3.21) | 0.50 | (0.30-0.83) |
| Calendar year, per year | ↓ 5-152 | ↓5-152 | 0.98 | (0.90-1.07) | 0.98 | (0.94-1.03) |
| Interval between diagnosis and transplantation, longer than 12 mo versus 12 mo or longer | ↑ 5-150 | ↓5-152 | 1.19 | (0.71-1.99) | 0.88 | (0.64-1.21) |
| cGvHD | ||||||
| 0 (reference) | (1) | (1) | ||||
| Limited | ↓5-152 | ↓ 5-153 | 0.90 | (0.4-2.1) | 0.54 | (0.34-0.79) |
| Extensive | ↑ 5-151 | ↓5-153 | 3.4 | (1.7-6.8) | 0.43 | (0.26-0.70) |
| Risk factor . | TRM . | RI . | TRM . | RI . | ||
|---|---|---|---|---|---|---|
| direction . | HR . | CI . | HR . | CI . | ||
| From transplantation until d 100 | ||||||
| aGvHD | ||||||
| Grade 0 (reference) | (1) | (1) | ||||
| Grade I | ↓ 5-153 | ↓5-152 | 0.58 | (0.44-0.76) | 0.47 | (0.18-1.19) |
| Grade II | ↓ 5-153 | ↓5-152 | 0.76 | (0.53-0.38) | 0.44 | (0.16-1.21) |
| Grade III | ↑ 5-151 | ↓ 5-152 | 2.09 | (1.6-2.7) | 0.53 | (0.12-2.32) |
| Grade IV | ↑ 5-151 | ↑5-150 | 6.55 | (5.3-8.1) | 1.31 | (0.38-4.54) |
| Age, per year | ↑ 5-151 | ↑ 5-150 | 1.02 | (1.01-1.03) | 1.00 | (0.97-1.04) |
| Sex, female vs male | ↓ 5-152 | ↑5-151 | 0.99 | (0.82-1.19) | 7.02 | (1.62-30.4) |
| Mismatch, female donor + male recipient versus rest | ↓ 5-152 | ↑5-151 | 0.97 | (0.79-1.19) | 8.73 | (1.97-38.8) |
| Calendar year, per year | ↓ 5-153 | ↑5-150 | 0.93 | (0.91-0.95) | 1.04 | (0.96-1.12) |
| Interval between diagnosis and transplantation, shorter than 12 mo versus 12 mo or longer | ↑ 5-151 | ↑ 5-150 | 1.4 | (1.2-1.7) | 1.30 | (0.64-2.64) |
| From d 100 until 3 y | ||||||
| aGvHD | ||||||
| Grade 0 (reference) | (1) | (1) | ||||
| Grade I | ↑ 5-151 | ↓ 5-153 | 1.52 | (1.19-1.96) | 0.94 | (0.76-1.16) |
| Grade II | ↑ 5-151 | ↓5-153 | 2.48 | (1.95-3.14) | 0.60 | (0.46-0.77) |
| Grade III | ↑ 5-151 | ↓ 5-153 | 5.76 | (4.44-7.48) | 0.48 | (0.29-0.81) |
| Grade IV | ↑ 5-151 | ↓5-153 | 14.7 | (10.9-19.9) | 0.14 | (0.02-0.99) |
| Age, per year | ↑ 5-151 | ↑ 5-151 | 1.03 | (1.02-1.04) | 1.01 | (1.00-1.02) |
| Sex, female versus male | ↑ 5-150 | ↓5-152 | 1.01 | (0.83-1.23) | 0.85 | (0.69-1.05) |
| Mismatch, female donor + male recipient versus rest | ↑ 5-151 | ↓5-152 | 1.36 | (1.11-1.66) | 0.98 | (0.77-1.25) |
| Calendar year, per year | ↓ 5-152 | ↓5-153 | 0.98 | (0.97-1.00) | 0.98 | (0.96-1.00) |
| Interval between diagnosis and transplantation, longer than 12 mo versus 12 mo or longer | ↑ 5-150 | ↑ 5-150 | 1.07 | (0.91-1.26) | 1.00 | (0.83-1.21) |
| From 3 y until 15 y | ||||||
| aGvHD | ||||||
| Grade 0 (reference) | (1) | (1) | ||||
| Grade I | ↓ 5-152 | ↑ 5-150 | 0.75 | (0.35-1.59) | 1.07 | (0.74-1.54) |
| Grade II | ↑ 5-150 | ↑5-150 | 1.03 | (0.52-2.06) | 1.05 | (0.68-1.61) |
| Grades III-IV | ↑ 5-151 | ↓5-152 | 2.94 | (1.45-5.95) | 0.34 | (0.11-1.09) |
| Age, per year | ↑ 5-151 | ↑ 5-150 | 1.04 | (1.01-1.07) | 1.01 | (0.99-1.03) |
| Sex, female versus male | ↓ 5-152 | ↓5-152 | 0.70 | (0.36-1.36) | 0.96 | (0.69-1.35) |
| Mismatch, female donor + male recipient versus rest | ↑ 5-150 | ↓5-153 | 1.72 | (0.93-3.21) | 0.50 | (0.30-0.83) |
| Calendar year, per year | ↓ 5-152 | ↓5-152 | 0.98 | (0.90-1.07) | 0.98 | (0.94-1.03) |
| Interval between diagnosis and transplantation, longer than 12 mo versus 12 mo or longer | ↑ 5-150 | ↓5-152 | 1.19 | (0.71-1.99) | 0.88 | (0.64-1.21) |
| cGvHD | ||||||
| 0 (reference) | (1) | (1) | ||||
| Limited | ↓5-152 | ↓ 5-153 | 0.90 | (0.4-2.1) | 0.54 | (0.34-0.79) |
| Extensive | ↑ 5-151 | ↓5-153 | 3.4 | (1.7-6.8) | 0.43 | (0.26-0.70) |
Cox models including recipient sex, sex-mismatch, age, calendar year, interval between diagnosis and transplantation, and aGvHD (and cGvHD after 3 years). Directions of effects always given, regardless of significance; ↑ indicates increasing hazard; ↓, decreasing hazard. Nonsignificant HRs are indicated with * and ‡.
Increasing hazard on outcome (P > .05).
Increasing hazard on outcome (P ≤ .05).
Decreasing hazard on outcome (P > .05).
Decreasing hazard on outcome (P ≤ .05).