Pretreatment karyotype and best response to imatinib in patients with clonal evolution without other accelerated phase features (AP-CE; n = 15)
| Case no. . | Pretreatment karyotype . | Best response . |
|---|---|---|
| 1 | 47, XY, t(9;22),+ t(9;22) [20] | (FISH 75.5%, Ph 100%) |
| 2 | 46, XX, t(9;22) [14]/47,idem,+ der(22)t(9;22) [6] | (FISH 10%, Ph 15%) |
| 3 | 47, XY, + 8, t(9;22)[7]/ 46, XY, t(9;22) [13] | (FISH 47%, Ph 100%) |
| 4 | 47, XY, + 8,t(9;22) [12]/ 47,XY, t(9;22),+ der(22)t(9;22) [7] | (FISH 3%, Ph 0% [11/11 negative]) |
| 5 | 46, XY, t(9;22;12) [2]/45,idem,der(16)t(16;17)(p13,3;q11,2), 17[7]/45,idem,der(17)t(17;17)(q25;p11.2), −17[3]45,idem, −17, der(19)t(17;19)(q11.2;p13.3)[2]/45,idem,der(4)t(4;17)(q16;q11.2), −17[2]/46,XY[3] | (FISH 0%, Ph 0%) |
| 6 | 46, XY, t(9;22) [4]/47,idem,+ 8,i(17)(q10)[1]/46,XY[1] | (FISH 0%, Ph 0%) |
| 7 | 46, XY,+ 8, t(9;22) [10], 46, XY[1] | (FISH 30.5%, Ph 90%) |
| 8 | 46, XX, t(9;22;14),del(12)(p1?3)[14] | (FISH 0%, Ph 0%) |
| 9 | 46, X,t(X;5)(p?11.4;q11.2),inv(1)(p22;q44), t(9;22) [20] | (FISH 5%, Ph 0%) |
| 10 | 46, XY, t(9;22) ([16]/46,idem,der(12)t(12;14)(q10;q10),add(13)(p11.2),− 14,+ mar[4] | (FISH 0%, Ph 0%) |
| 11 | 46, XY, t(8;10)(q?21;q?23),t(9;22) [10]/46,XY[10] | (FISH 0.3%, Ph 0%) |
| 12 | 46, XY, t(9;22) ?add(11)(p13)[2]/46,idem,?del(4)(p14p15.2)[4] | (FISH 2%, Ph 0%) |
| 13 | 46, XY, t(9;22) [15]/46,idem,del(7)(q22)[2] | (FISH 17.5%, Ph 0%) |
| 14 | 46, XY,t(9;22) [6]/46,idem,der(12)t(3;12)(q21;q11),iso(12)(q10)[7]/ 46,idem, add(4)(q12), der(9)t(4;9)(q11;p11), del(11)(q21)[3]/ 46,idem,add(4)(q12), der(9)t(4;9)(q11;p11),del(11)(q21),add(14)(q24)[3] | (FISH 24.5%, Ph 55%) |
| 15 | 46, XX,t(1;2)(q21;q21), t(9;22) [15]/46,idem,t(15;19)(q15;q13.3)[2]/46,idem,del(7)(q32),t(15;19) (q15;p13.3)[2]/46,XX[1] | (FISH 0%, Ph 0%) |
| Case no. . | Pretreatment karyotype . | Best response . |
|---|---|---|
| 1 | 47, XY, t(9;22),+ t(9;22) [20] | (FISH 75.5%, Ph 100%) |
| 2 | 46, XX, t(9;22) [14]/47,idem,+ der(22)t(9;22) [6] | (FISH 10%, Ph 15%) |
| 3 | 47, XY, + 8, t(9;22)[7]/ 46, XY, t(9;22) [13] | (FISH 47%, Ph 100%) |
| 4 | 47, XY, + 8,t(9;22) [12]/ 47,XY, t(9;22),+ der(22)t(9;22) [7] | (FISH 3%, Ph 0% [11/11 negative]) |
| 5 | 46, XY, t(9;22;12) [2]/45,idem,der(16)t(16;17)(p13,3;q11,2), 17[7]/45,idem,der(17)t(17;17)(q25;p11.2), −17[3]45,idem, −17, der(19)t(17;19)(q11.2;p13.3)[2]/45,idem,der(4)t(4;17)(q16;q11.2), −17[2]/46,XY[3] | (FISH 0%, Ph 0%) |
| 6 | 46, XY, t(9;22) [4]/47,idem,+ 8,i(17)(q10)[1]/46,XY[1] | (FISH 0%, Ph 0%) |
| 7 | 46, XY,+ 8, t(9;22) [10], 46, XY[1] | (FISH 30.5%, Ph 90%) |
| 8 | 46, XX, t(9;22;14),del(12)(p1?3)[14] | (FISH 0%, Ph 0%) |
| 9 | 46, X,t(X;5)(p?11.4;q11.2),inv(1)(p22;q44), t(9;22) [20] | (FISH 5%, Ph 0%) |
| 10 | 46, XY, t(9;22) ([16]/46,idem,der(12)t(12;14)(q10;q10),add(13)(p11.2),− 14,+ mar[4] | (FISH 0%, Ph 0%) |
| 11 | 46, XY, t(8;10)(q?21;q?23),t(9;22) [10]/46,XY[10] | (FISH 0.3%, Ph 0%) |
| 12 | 46, XY, t(9;22) ?add(11)(p13)[2]/46,idem,?del(4)(p14p15.2)[4] | (FISH 2%, Ph 0%) |
| 13 | 46, XY, t(9;22) [15]/46,idem,del(7)(q22)[2] | (FISH 17.5%, Ph 0%) |
| 14 | 46, XY,t(9;22) [6]/46,idem,der(12)t(3;12)(q21;q11),iso(12)(q10)[7]/ 46,idem, add(4)(q12), der(9)t(4;9)(q11;p11), del(11)(q21)[3]/ 46,idem,add(4)(q12), der(9)t(4;9)(q11;p11),del(11)(q21),add(14)(q24)[3] | (FISH 24.5%, Ph 55%) |
| 15 | 46, XX,t(1;2)(q21;q21), t(9;22) [15]/46,idem,t(15;19)(q15;q13.3)[2]/46,idem,del(7)(q32),t(15;19) (q15;p13.3)[2]/46,XX[1] | (FISH 0%, Ph 0%) |