Table 3. Pathologic parameters of... | American Society of Hematology

Table 3.

Pathologic parameters of leukemic mice injected with clonally expanded BCR-ABL transduced cells.

Donor genotype	Recipient genotype	Disease^3-150 latency	WBC^3-151(× 10⁶/mL)	Differential counts (%)					Spleen weight (g)	GFP⁺ cells in PB, BM
Donor genotype	Recipient genotype	Disease^3-150 latency	WBC^3-151(× 10⁶/mL)	Gr	Ly	Mo	Baso	Eo	Spleen weight (g)	GFP⁺ cells in PB, BM
+/+	β2m	57 ± 7.5	9.5 ± 3	88 ± 4	8 ± 4	3 ± 1	2 ± 1	0	0.25 ± 0.03	(+)
+/+	NOD/SCID	71 ± 7.3	8.5 ± 2	87 ± 2	11 ± 2	4 ± 2	1 ± 0.5	0	0.18 ± 0.05	(+)
IL-3^−/−	β2m	>120	1.1 ± 0.2	74 ± 2	24 ± 4	5 ± 2	0.5 ± 0.3	0	0.04 ± 0.003	(−)
IL-3^−/−	NOD/SCID	>120	1.0 ± 0.1	76 ± 4	19 ± 4	7 ± 1	0.5 ± 0.3	0	0.04 ± 0.005	(−)
β2m control		—	1.0 ± 0.3	67 ± 5	26 ± 5	9 ± 2	0.5 ± 0.3	0	0.05 ± 0.005
NOD/SCID control		—	1.2 ± 0.2	71 ± 3	24 ± 3	7 ± 2	0	0.5 ± 0.3	0.04 ± 0.005

Donor genotype	Recipient genotype	Disease^3-150 latency	WBC^3-151(× 10⁶/mL)	Differential counts (%)					Spleen weight (g)	GFP⁺ cells in PB, BM
Donor genotype	Recipient genotype	Disease^3-150 latency	WBC^3-151(× 10⁶/mL)	Gr	Ly	Mo	Baso	Eo	Spleen weight (g)	GFP⁺ cells in PB, BM
+/+	β2m	57 ± 7.5	9.5 ± 3	88 ± 4	8 ± 4	3 ± 1	2 ± 1	0	0.25 ± 0.03	(+)
+/+	NOD/SCID	71 ± 7.3	8.5 ± 2	87 ± 2	11 ± 2	4 ± 2	1 ± 0.5	0	0.18 ± 0.05	(+)
IL-3^−/−	β2m	>120	1.1 ± 0.2	74 ± 2	24 ± 4	5 ± 2	0.5 ± 0.3	0	0.04 ± 0.003	(−)
IL-3^−/−	NOD/SCID	>120	1.0 ± 0.1	76 ± 4	19 ± 4	7 ± 1	0.5 ± 0.3	0	0.04 ± 0.005	(−)
β2m control		—	1.0 ± 0.3	67 ± 5	26 ± 5	9 ± 2	0.5 ± 0.3	0	0.05 ± 0.005
NOD/SCID control		—	1.2 ± 0.2	71 ± 3	24 ± 3	7 ± 2	0	0.5 ± 0.3	0.04 ± 0.005

Gr, indicates granulocytes; Ly, lymphocytes; Mo, monocytes; Baso, basophils; Eo, eosinophils; PB, peripheral blood; BM, bone marrow.

Time (in days) to death due to leukemia.

Maximum WBC count prior to death.