Mean estimates of HSC parameters
| . | Lifetime, y . | HSC replication rate, wk . | No. HSC replications/lifetime . | Size, kg . | No. marrow cells . | No. marrow cells/kg . | Frequency of HSCs . | No. HSCs/animal . |
|---|---|---|---|---|---|---|---|---|
| Mouse | 2 | 1/2.5 | 42 | 0.02 | 2.8 × 108 | 1.4 × 1010 | 4/105-8/105 | 11 200-22 400 |
| Cat | 15 | 1/10-1/8 | 78-98 | 3.00 | 1.9 × 1010 | 0.6 × 1010 | 6/107 | 11 400 |
| Human | 80 | (1/42) | (100) | 70.00 | 1.5 × 1012 | 2.1 × 1010 | (0.7/108-1.5/108) | (11 200-22 400) |
| . | Lifetime, y . | HSC replication rate, wk . | No. HSC replications/lifetime . | Size, kg . | No. marrow cells . | No. marrow cells/kg . | Frequency of HSCs . | No. HSCs/animal . |
|---|---|---|---|---|---|---|---|---|
| Mouse | 2 | 1/2.5 | 42 | 0.02 | 2.8 × 108 | 1.4 × 1010 | 4/105-8/105 | 11 200-22 400 |
| Cat | 15 | 1/10-1/8 | 78-98 | 3.00 | 1.9 × 1010 | 0.6 × 1010 | 6/107 | 11 400 |
| Human | 80 | (1/42) | (100) | 70.00 | 1.5 × 1012 | 2.1 × 1010 | (0.7/108-1.5/108) | (11 200-22 400) |
Values in parentheses are extrapolations (see “Results and discussion”).