Effect of 4.1R Coimbra mutation on cell proliferation
| Blood sample . | Erythroid cells* . | Lymphoid cells† . | |
|---|---|---|---|
| Day 7 . | Day 14 . | Population-doubling time . | |
| Control | 16.6 (10.4/22.8) | 19.8 (14.6/25.0) | 40.3 ± 8.0 |
| Heterozygote | 13.6 | 16.6 | 44 |
| Homozygote | 11.0 | 12.8 | 46.0 ± 8.0 |
| Blood sample . | Erythroid cells* . | Lymphoid cells† . | |
|---|---|---|---|
| Day 7 . | Day 14 . | Population-doubling time . | |
| Control | 16.6 (10.4/22.8) | 19.8 (14.6/25.0) | 40.3 ± 8.0 |
| Heterozygote | 13.6 | 16.6 | 44 |
| Homozygote | 11.0 | 12.8 | 46.0 ± 8.0 |
The number of BFU-Es obtained in standard methylcellulose assay after 7 and 14 days of culture is expressed as a mean of 4 experiments (minimum/ maximum values).
Population-doubling time of EBV-transformed cell lines calculated during exponential growth phase by the formula T = [(t1 − t0) × log 2]/(log n1 − log n0), with n1 and n0 being the numbers of cells at times t1 and t0.