Factors in children that affect the action of UFH
| UFH factor . | Age-related difference . |
|---|---|
| UFH acts via antithrombin-mediated catabolism of thrombin and factor Xa | Reduced levels of antithrombin and prothrombin |
| Reduced capacity to generate thrombin | |
| Age related difference in anti–factor Xa/anti–factor IIa activity of UFH | |
| UFH is bound to plasma proteins, which limits free active UFH | Alterations in plasma binding |
| Endothelial release of TFPI | Age-related differences in amount of TFPI release for same amount of UFH |
| UFH factor . | Age-related difference . |
|---|---|
| UFH acts via antithrombin-mediated catabolism of thrombin and factor Xa | Reduced levels of antithrombin and prothrombin |
| Reduced capacity to generate thrombin | |
| Age related difference in anti–factor Xa/anti–factor IIa activity of UFH | |
| UFH is bound to plasma proteins, which limits free active UFH | Alterations in plasma binding |
| Endothelial release of TFPI | Age-related differences in amount of TFPI release for same amount of UFH |