OR for faster myeloid engraftment, according to cell dose per kilogram (before cryopreservation)
Variable . | No. of patients . | OR for faster time to ANC ≥ 500 . | |
---|---|---|---|
Univariate (95% CI;P) . | Multivariate (95% CI; P) . | ||
NRBCs/kg (× 106) | |||
< 1.0 | 309 | 1.0 | 1.0 |
2.0-1.9 | 207 | 1.1 (0.9-1.4; .25) | 1.1 (0.8-1.3; .6) |
2.0-3.9 | 202 | 1.6 (1.3-1.9; < .001) | 1.4 (1.1-1.8; .002) |
≥ 4.0 | 308 | 1.7 (1.4-2.1; < .001) | 1.3 (1.03-1.6; .026) |
WBCs/kg (× 106): | |||
< 25 | 331 | 1.0 | 1.0 |
25-49 | 335 | 1.3 (1.1-1.6; .003) | 1.3 (1.1-1.6; .011) |
50-99 | 238 | 1.7 (1.4-2.1; < .001) | 1.6 (1.3-2.0; < .001) |
≥ 100 | 122 | 2.8 (2.2-3.6; < .001) | 2.5 (1.9-3.3; < .001) |
Variable . | No. of patients . | OR for faster time to ANC ≥ 500 . | |
---|---|---|---|
Univariate (95% CI;P) . | Multivariate (95% CI; P) . | ||
NRBCs/kg (× 106) | |||
< 1.0 | 309 | 1.0 | 1.0 |
2.0-1.9 | 207 | 1.1 (0.9-1.4; .25) | 1.1 (0.8-1.3; .6) |
2.0-3.9 | 202 | 1.6 (1.3-1.9; < .001) | 1.4 (1.1-1.8; .002) |
≥ 4.0 | 308 | 1.7 (1.4-2.1; < .001) | 1.3 (1.03-1.6; .026) |
WBCs/kg (× 106): | |||
< 25 | 331 | 1.0 | 1.0 |
25-49 | 335 | 1.3 (1.1-1.6; .003) | 1.3 (1.1-1.6; .011) |
50-99 | 238 | 1.7 (1.4-2.1; < .001) | 1.6 (1.3-2.0; < .001) |
≥ 100 | 122 | 2.8 (2.2-3.6; < .001) | 2.5 (1.9-3.3; < .001) |
Results are from a Cox regression analysis. The analysis excluded 83 patients whose time to achieve an ANC of at least 500 was unknown, 2 patients whose NRBC dose was unknown, and 16 patients who died or relapsed before posttransplantation day 9, the day that the first patient had engraftment.