Table 2.

OR for faster myeloid engraftment, according to cell dose per kilogram (before cryopreservation)

VariableNo. of
patients
OR for faster time to ANC ≥ 500
Univariate (95% CI;P)Multivariate (95% CI; P)
NRBCs/kg (× 106   
 < 1.0 309 1.0 1.0 
 2.0-1.9 207 1.1  (0.9-1.4; .25) 1.1  (0.8-1.3; .6) 
 2.0-3.9 202 1.6  (1.3-1.9; < .001) 1.4  (1.1-1.8; .002)  
 ≥ 4.0 308 1.7  (1.4-2.1; < .001) 1.3  (1.03-1.6; .026)  
WBCs/kg (× 106):    
 < 25 331 1.0 1.0 
 25-49 335 1.3  (1.1-1.6; .003) 1.3  (1.1-1.6; .011) 
 50-99 238 1.7  (1.4-2.1; < .001) 1.6  (1.3-2.0; < .001)  
 ≥ 100 122 2.8  (2.2-3.6; < .001) 2.5  (1.9-3.3; < .001) 
VariableNo. of
patients
OR for faster time to ANC ≥ 500
Univariate (95% CI;P)Multivariate (95% CI; P)
NRBCs/kg (× 106   
 < 1.0 309 1.0 1.0 
 2.0-1.9 207 1.1  (0.9-1.4; .25) 1.1  (0.8-1.3; .6) 
 2.0-3.9 202 1.6  (1.3-1.9; < .001) 1.4  (1.1-1.8; .002)  
 ≥ 4.0 308 1.7  (1.4-2.1; < .001) 1.3  (1.03-1.6; .026)  
WBCs/kg (× 106):    
 < 25 331 1.0 1.0 
 25-49 335 1.3  (1.1-1.6; .003) 1.3  (1.1-1.6; .011) 
 50-99 238 1.7  (1.4-2.1; < .001) 1.6  (1.3-2.0; < .001)  
 ≥ 100 122 2.8  (2.2-3.6; < .001) 2.5  (1.9-3.3; < .001) 

Results are from a Cox regression analysis. The analysis excluded 83 patients whose time to achieve an ANC of at least 500 was unknown, 2 patients whose NRBC dose was unknown, and 16 patients who died or relapsed before posttransplantation day 9, the day that the first patient had engraftment.

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