Characteristics of 220 patients with normal cytogenetics according to FLT3 mutation status
| . | No FLT3 mutation, n = 125 . | FLT3 Asp835 mutation, n = 8 . | FLT3ITD, n = 67 . | P . |
|---|---|---|---|---|
| Male sex, % | 51 | 43 | 36 | .12 |
| Median age, y | 47 | 47 | 47 | .71 |
| Range | 16-60 | 16-60 | 19-60 | |
| Secondary disease status, % | 18 | 4 | 3 | .002 |
| Median Hb level, g/dL | 8.9 | 9.1 | 8.9 | .95 |
| Range | 4.8-8.8 | 4.1-14.9 | 5.3-13.2 | |
| Median platelets, ×109/L | 53 | 70 | 62 | .12 |
| Range | 5-746 | 11-361 | 12-248 | |
| Median WBC count, ×109/L | 12.5 | 24.8 | 44.8 | .0002 |
| Range | 0.2-369 | 2.2-202 | 0.7-345 | |
| Median PB blasts, % | 35 | 43 | 65 | .001 |
| Range | 9-99 | 0-89 | 2-100 | |
| Median BM blasts, % | 76 | 90 | 90 | .0002 |
| Range | 0-100 | 28-90 | 9-100 | |
| Median LDH, U/L | 420 | 372 | 643 | .0005 |
| Range | 89-1871 | 176-1650 | 122-4091 | |
| Lymphadenopathy, % | 22 (n = 117) | 22 (n = 27) | 22 (n = 65) | 1.0 |
| Extramedullary involvement, % | 9 (n = 117) | 11 (n = 27) | 9 (n = 64) | .88 |
| MLL PTD, % | 6 (n = 121) | 8 | 9 (n = 66) | .64 |
| . | No FLT3 mutation, n = 125 . | FLT3 Asp835 mutation, n = 8 . | FLT3ITD, n = 67 . | P . |
|---|---|---|---|---|
| Male sex, % | 51 | 43 | 36 | .12 |
| Median age, y | 47 | 47 | 47 | .71 |
| Range | 16-60 | 16-60 | 19-60 | |
| Secondary disease status, % | 18 | 4 | 3 | .002 |
| Median Hb level, g/dL | 8.9 | 9.1 | 8.9 | .95 |
| Range | 4.8-8.8 | 4.1-14.9 | 5.3-13.2 | |
| Median platelets, ×109/L | 53 | 70 | 62 | .12 |
| Range | 5-746 | 11-361 | 12-248 | |
| Median WBC count, ×109/L | 12.5 | 24.8 | 44.8 | .0002 |
| Range | 0.2-369 | 2.2-202 | 0.7-345 | |
| Median PB blasts, % | 35 | 43 | 65 | .001 |
| Range | 9-99 | 0-89 | 2-100 | |
| Median BM blasts, % | 76 | 90 | 90 | .0002 |
| Range | 0-100 | 28-90 | 9-100 | |
| Median LDH, U/L | 420 | 372 | 643 | .0005 |
| Range | 89-1871 | 176-1650 | 122-4091 | |
| Lymphadenopathy, % | 22 (n = 117) | 22 (n = 27) | 22 (n = 65) | 1.0 |
| Extramedullary involvement, % | 9 (n = 117) | 11 (n = 27) | 9 (n = 64) | .88 |
| MLL PTD, % | 6 (n = 121) | 8 | 9 (n = 66) | .64 |
Hb indicates hemoglobin.