Characteristics of cases and transfused controls from the TRALI Specialized Clinical Center for Outcomes Research
| Patient characteristic . | TRALI, n = 89 . | Possible TRALI, n = 130 . | TACO, n = 83 . | Control, n = 164 . |
|---|---|---|---|---|
| Units transfused* | 4 (2-13) | 3 (2-5) | 4 (2-10) | 3 (2-10) |
| Blood component type | ||||
| Red blood cells | 67 (75%) | 83 (64%) | 66 (80%) | 127 (77%) |
| Plasma | 59 (66%) | 70 (54%) | 46 (55%) | 81 (49%) |
| Platelets | 37 (42%) | 52 (40%) | 43 (52%) | 56 (34% |
| Comorbid characteristics | ||||
| History of congestive heart failure | 7 (8%) | 8 (6%) | 29 (35%) | 13 (8%) |
| Coronary artery disease | 15 (17%) | 31 (24%) | 34 (41%) | 30 (18%) |
| Acute renal failure | 23 (26%) | 34 (26%) | 15 (18%) | 17 (10%) |
| Chronic renal failure | 5 (6%) | 11 (12%) | 15 (18%) | 14 (9%) |
| Severe liver disease | 21 (24%) | 20 (15%) | 9 (11%) | 15 (9%) |
| Chronic alcohol abuse | 12 (13%) | 17 (13%) | 5 (6%) | 6 (4%) |
| History of tobacco use | 18 (20%) | 27 (21%) | 11 (13%) | 18 (11%) |
| Hematologic malignancy | 6 (7%) | 25 (19%) | 6 (7%) | 30 (18%) |
| Recent surgery | 54 (61%) | 49 (38%) | 62 (75%) | 68 (41%) |
| Clinical characteristics | ||||
| Shock before transfusion | 39 (44%) | 59 (45%) | 32 (39%) | 30 (18%) |
| Ventilation after transfusion | 42 (47%) | 68 (52%) | 56 (67%) | 39 (24%) |
| Fluid balance, L | 3.7 (1.6-7.3) | 4.5 (1.7-7.7) | 3.7 (1.6-6) | 2.0 (0.4-4.5) |
| BNP after transfusion, pg/mL† | 252 (133-593) | 693 (361-1370) | 1907 (1108-2339) | 373 (291-589) |
| Patient characteristic . | TRALI, n = 89 . | Possible TRALI, n = 130 . | TACO, n = 83 . | Control, n = 164 . |
|---|---|---|---|---|
| Units transfused* | 4 (2-13) | 3 (2-5) | 4 (2-10) | 3 (2-10) |
| Blood component type | ||||
| Red blood cells | 67 (75%) | 83 (64%) | 66 (80%) | 127 (77%) |
| Plasma | 59 (66%) | 70 (54%) | 46 (55%) | 81 (49%) |
| Platelets | 37 (42%) | 52 (40%) | 43 (52%) | 56 (34% |
| Comorbid characteristics | ||||
| History of congestive heart failure | 7 (8%) | 8 (6%) | 29 (35%) | 13 (8%) |
| Coronary artery disease | 15 (17%) | 31 (24%) | 34 (41%) | 30 (18%) |
| Acute renal failure | 23 (26%) | 34 (26%) | 15 (18%) | 17 (10%) |
| Chronic renal failure | 5 (6%) | 11 (12%) | 15 (18%) | 14 (9%) |
| Severe liver disease | 21 (24%) | 20 (15%) | 9 (11%) | 15 (9%) |
| Chronic alcohol abuse | 12 (13%) | 17 (13%) | 5 (6%) | 6 (4%) |
| History of tobacco use | 18 (20%) | 27 (21%) | 11 (13%) | 18 (11%) |
| Hematologic malignancy | 6 (7%) | 25 (19%) | 6 (7%) | 30 (18%) |
| Recent surgery | 54 (61%) | 49 (38%) | 62 (75%) | 68 (41%) |
| Clinical characteristics | ||||
| Shock before transfusion | 39 (44%) | 59 (45%) | 32 (39%) | 30 (18%) |
| Ventilation after transfusion | 42 (47%) | 68 (52%) | 56 (67%) | 39 (24%) |
| Fluid balance, L | 3.7 (1.6-7.3) | 4.5 (1.7-7.7) | 3.7 (1.6-6) | 2.0 (0.4-4.5) |
| BNP after transfusion, pg/mL† | 252 (133-593) | 693 (361-1370) | 1907 (1108-2339) | 373 (291-589) |
Subjects are from the TRALI Specialized Clinical Center for Outcomes Research study (from 2006 to 2009).1 Data are reported as median values (interquartile ranges) or numbers (percentages).
Number of blood components transfused in the 6 hours before development of pulmonary edema for cases.
This is a subset of the total BNP after transfusion (n = 98), pg/mL.