The complications of polycythemia vera
| Complication . | Cause . |
|---|---|
| Thrombosis, hypertension | Elevated red cell mass |
| Organomegaly | Elevated red cell mass or extramedullary hematopoiesis |
| Pruritis, acid-peptic disease | Inflammatory mediators or elevated red cell mass |
| Hyperuricemia, gout, renal stones | Increased cell turnover |
| Erythromelalgia or ocular migraine | Thrombocytosis |
| Hemorrhage | Elevated red cell mass, or acquired von Willebrand disease due to thrombocytosis |
| Myelofibrosis | Reaction to the neoplastic clone |
| Wasting syndrome | Disease acceleration |
| Acute leukemia | Therapy-related or clonal evolution |
| Complication . | Cause . |
|---|---|
| Thrombosis, hypertension | Elevated red cell mass |
| Organomegaly | Elevated red cell mass or extramedullary hematopoiesis |
| Pruritis, acid-peptic disease | Inflammatory mediators or elevated red cell mass |
| Hyperuricemia, gout, renal stones | Increased cell turnover |
| Erythromelalgia or ocular migraine | Thrombocytosis |
| Hemorrhage | Elevated red cell mass, or acquired von Willebrand disease due to thrombocytosis |
| Myelofibrosis | Reaction to the neoplastic clone |
| Wasting syndrome | Disease acceleration |
| Acute leukemia | Therapy-related or clonal evolution |