Allele frequencies and genotype/haplotype distributions at positions −308 and −238 of the TNF-α gene promoter in 255 multiple myeloma (MM) patients (pts), including 81 Thal-treated pts with relapsed and refractory MM; in addition, 200 healthy, local blood donors were analyzed as controls
| Characteristic . | All MM pts . | Controls . | P* . | ||
|---|---|---|---|---|---|
| No. . | (%) . | No. . | (%) . | ||
| Codon −308 | |||||
| Allele | |||||
| G | 425 | (83.3) | 341 | (85.3) | .49 |
| A | 85 | (16.7) | 59 | (14.7) | |
| Genotypes | |||||
| GG | 184 | (72.1) | 142 | (71.0) | .006 |
| GA | 57 | (22.3) | 57 | (28.5) | |
| AA | 14 | (5.5) | 1 | (0.5) | |
| Codon −238 | |||||
| Allele | |||||
| G | 491 | (96.3) | 377 | (94.3) | .20 |
| A | 19 | (3.7) | 23 | (5.7) | |
| Genotypes | |||||
| GG | 236 | (92.5) | 177 | (88.5) | .15 |
| GA | 19 | (7.5) | 23 | (11.5) | |
| AA | 0 | (0.0) | 0 | (0.0) | |
| Codons −308 and −238 (1. allele/2. allele) | |||||
| Haplotypes | |||||
| GG/GG | 166 | (65.1) | 122 | (61.0) | .01 |
| AG/GG | 56 | (22.0) | 54 | (27.0) | |
| GA/GG | 18 | (7.1) | 20 | (10.0) | |
| AG/AG | 14 | (5.5) | 1 | (0.5) | |
| AG/GA | 1 | (0.4) | 3 | (1.5) | |
| Characteristic . | All MM pts . | Controls . | P* . | ||
|---|---|---|---|---|---|
| No. . | (%) . | No. . | (%) . | ||
| Codon −308 | |||||
| Allele | |||||
| G | 425 | (83.3) | 341 | (85.3) | .49 |
| A | 85 | (16.7) | 59 | (14.7) | |
| Genotypes | |||||
| GG | 184 | (72.1) | 142 | (71.0) | .006 |
| GA | 57 | (22.3) | 57 | (28.5) | |
| AA | 14 | (5.5) | 1 | (0.5) | |
| Codon −238 | |||||
| Allele | |||||
| G | 491 | (96.3) | 377 | (94.3) | .20 |
| A | 19 | (3.7) | 23 | (5.7) | |
| Genotypes | |||||
| GG | 236 | (92.5) | 177 | (88.5) | .15 |
| GA | 19 | (7.5) | 23 | (11.5) | |
| AA | 0 | (0.0) | 0 | (0.0) | |
| Codons −308 and −238 (1. allele/2. allele) | |||||
| Haplotypes | |||||
| GG/GG | 166 | (65.1) | 122 | (61.0) | .01 |
| AG/GG | 56 | (22.0) | 54 | (27.0) | |
| GA/GG | 18 | (7.1) | 20 | (10.0) | |
| AG/AG | 14 | (5.5) | 1 | (0.5) | |
| AG/GA | 1 | (0.4) | 3 | (1.5) | |
The exact χ2 test was used to assess differences in allele frequencies and genotype/haplotype distributions between 255 MM pts and 200 controls.