Mechanisms of DITP
| Type of antibody . | Mechanism . | Example of drugs . |
|---|---|---|
| Quinine type | Drug binds DDAbs and subsequently, platelet integrin | Quinine, sulfonamide antibiotics, nonsteroidal anti-inflammatory drugs |
| Hapten dependent | Drug links covalently to membrane protein and induces drug-specific binding by DDAbs | Penicillin, some cephalosporin antibiotics |
| Fiban type | Drug reacts with glycoprotein IIb/IIIa and induces neoepitope(s) for the DDAbs | Tirofiban, eptifibatide |
| Drug specific | DDAbs recognize the murine component of chimeric Fab fragment specific for glycoprotein IIIa | Abciximab |
| Autoantibody | Drug induces antibody that reacts with autologous platelets in the absence of drug | Gold salts, procainamide |
| Immune complexes | Antibodies form immune complexes with their target antigens | Heparin, protamine |
| Type of antibody . | Mechanism . | Example of drugs . |
|---|---|---|
| Quinine type | Drug binds DDAbs and subsequently, platelet integrin | Quinine, sulfonamide antibiotics, nonsteroidal anti-inflammatory drugs |
| Hapten dependent | Drug links covalently to membrane protein and induces drug-specific binding by DDAbs | Penicillin, some cephalosporin antibiotics |
| Fiban type | Drug reacts with glycoprotein IIb/IIIa and induces neoepitope(s) for the DDAbs | Tirofiban, eptifibatide |
| Drug specific | DDAbs recognize the murine component of chimeric Fab fragment specific for glycoprotein IIIa | Abciximab |
| Autoantibody | Drug induces antibody that reacts with autologous platelets in the absence of drug | Gold salts, procainamide |
| Immune complexes | Antibodies form immune complexes with their target antigens | Heparin, protamine |
DDAb, drug-dependent antibody.