Frequency and characteristics of nonprioritized cytogenetic subgroups
| Cytogenetic abnormality . | No. of patients (%) . | Median age (% younger than 60 y) . | No. of patients with a sole abnormality (%) . | No. of patients with 3 or more abnormalities (%) . | No. of patients with 5 or more abnormalities (%) . |
|---|---|---|---|---|---|
| Normal | 582 (48.0) | 54 (64) | NA | NA | NA |
| +8 | 123 (10.1) | 58 (54) | 41 (31) | 43 (35) | 20 (16) |
| inv(16) or t(16;16) | 96 (7.9) | 40 (84) | 64 (67) | 8 (8) | 1 (1) |
| −7/7q− | 95 (7.8) | 64 (38) | 17 (18) | 62 (65) | 47 (49) |
| −7 | 47 (3.9) | 65 (38) | 11 (23) | 26 (55) | 19 (40) |
| Loss of 7q | 29 (2.4) | 65 (28) | 3 (10) | 20 (69) | 17 (59) |
| del(7q) | 19 (1.6) | 59 (53) | 3 (16) | 16 (84) | 11 (58) |
| −5/5q− | 86 (7.1) | 66 (30) | 4 (5) | 77 (90) | 74 (86) |
| del(5q) | 42 (3.5) | 66 (31) | 1 (2) | 37 (88) | 34 (81) |
| −5 | 26 (2.1) | 64 (27) | 1 (4) | 25 (96) | 25 (96) |
| Loss of 5q | 18 (1.5) | 62 (33) | 2 (11) | 15 (83) | 15 (83) |
| t(8;21) | 81 (6.7) | 34 (90) | 22 (27) | 14 (17) | 2 (2) |
| −17/17p− | 62 (5.1) | 64 (34) | 0 (0) | 60 (97) | 58 (94) |
| −17 | 32 (2.6) | 66 (28) | 0 (0) | 30 (94) | 29 (91) |
| Loss of 17p | 30 (2.5) | 63 (40) | 0 (0) | 30 (100) | 29 (97) |
| −Y | 58 (4.8) | 49 (62) | 14 (29) | 17 (29) | 7 (12) |
| Balanced abn(11q23) | 54 (4.5) | 42 (83) | 27 (50) | 15 (28) | 4 (7) |
| t(9;11) | 27 (2.2) | 42 (89) | 12 (44) | 8 (30) | 3 (11) |
| t(11;v)3-150 | 13 (1.1) | 36 (77) | 5 (38) | 6 (46) | 1 (8) |
| t(6;11) | 8 (0.7) | 46 (100) | 5 (63) | 1 (13) | 0 (0) |
| t(11;19)(q23;p13.1) | 6 (0.5) | 57 (50) | 5 (83) | 0 (0) | 0 (0) |
| −20/20q− | 39 (3.2) | 60 (44) | 6 (15) | 29 (74) | 28 (72) |
| del(20q) | 16 (1.3) | 65 (44) | 5 (31) | 9 (56) | 8 (50) |
| −20 | 15 (1.2) | 60 (47) | 1 (7) | 12 (80) | 12 (80) |
| Loss of 20q | 8 (0.7) | 61 (38) | 0 (0) | 8 (100) | 8 (100) |
| del(9q) | 33 (2.7) | 37 (82) | 11 (33) | 10 (30) | 2 (6) |
| abn(12p) | 33 (2.7) | 64 (36) | 1 (3) | 25 (76) | 21 (64) |
| Unbalanced abn(12p) | 25 (2.1) | 64 (32) | 1 (4) | 20 (80) | 16 (64) |
| Balanced abn(12p) | 8 (0.7) | 61 (50) | 0 (0) | 5 (63) | 5 (63) |
| +22 | 31 (2.6) | 59 (55) | 1 (3) | 19 (61) | 14 (45) |
| −18 | 30 (2.5) | 64 (30) | 1 (3) | 29 (97) | 28 (93) |
| +13 | 29 (2.4) | 59 (55) | 13 (45) | 12 (41) | 10 (34) |
| +21 | 28 (2.3) | 59 (54) | 5 (24) | 14 (50) | 10 (36) |
| +11 | 20 (1.6) | 65 (20) | 12 (60) | 7 (35) | 6 (30) |
| −X | 18 (1.5) | 44 (67) | 0 (0) | 8 (44) | 5 (28) |
| +4 | 14 (1.2) | 55 (57) | 2 (14) | 10 (71) | 6 (43) |
| +14 | 12 (1.0) | 64 (42) | 0 (0) | 10 (83) | 9 (75) |
| del(11q) | 12 (1.0) | 42 (58) | 4 (33) | 5 (42) | 3 (25) |
| inv(3) or t(3;3) | 12 (1.0) | 43 (83) | 2 (17) | 4 (33) | 1 (8) |
| del(13q) | 9 (0.7) | 44 (56) | 1 (11) | 7 (78) | 5 (56) |
| t(6;9) | 8 (0.7) | 33 (100) | 6 (75) | 0 (0) | 0 (0) |
| Cytogenetic abnormality . | No. of patients (%) . | Median age (% younger than 60 y) . | No. of patients with a sole abnormality (%) . | No. of patients with 3 or more abnormalities (%) . | No. of patients with 5 or more abnormalities (%) . |
|---|---|---|---|---|---|
| Normal | 582 (48.0) | 54 (64) | NA | NA | NA |
| +8 | 123 (10.1) | 58 (54) | 41 (31) | 43 (35) | 20 (16) |
| inv(16) or t(16;16) | 96 (7.9) | 40 (84) | 64 (67) | 8 (8) | 1 (1) |
| −7/7q− | 95 (7.8) | 64 (38) | 17 (18) | 62 (65) | 47 (49) |
| −7 | 47 (3.9) | 65 (38) | 11 (23) | 26 (55) | 19 (40) |
| Loss of 7q | 29 (2.4) | 65 (28) | 3 (10) | 20 (69) | 17 (59) |
| del(7q) | 19 (1.6) | 59 (53) | 3 (16) | 16 (84) | 11 (58) |
| −5/5q− | 86 (7.1) | 66 (30) | 4 (5) | 77 (90) | 74 (86) |
| del(5q) | 42 (3.5) | 66 (31) | 1 (2) | 37 (88) | 34 (81) |
| −5 | 26 (2.1) | 64 (27) | 1 (4) | 25 (96) | 25 (96) |
| Loss of 5q | 18 (1.5) | 62 (33) | 2 (11) | 15 (83) | 15 (83) |
| t(8;21) | 81 (6.7) | 34 (90) | 22 (27) | 14 (17) | 2 (2) |
| −17/17p− | 62 (5.1) | 64 (34) | 0 (0) | 60 (97) | 58 (94) |
| −17 | 32 (2.6) | 66 (28) | 0 (0) | 30 (94) | 29 (91) |
| Loss of 17p | 30 (2.5) | 63 (40) | 0 (0) | 30 (100) | 29 (97) |
| −Y | 58 (4.8) | 49 (62) | 14 (29) | 17 (29) | 7 (12) |
| Balanced abn(11q23) | 54 (4.5) | 42 (83) | 27 (50) | 15 (28) | 4 (7) |
| t(9;11) | 27 (2.2) | 42 (89) | 12 (44) | 8 (30) | 3 (11) |
| t(11;v)3-150 | 13 (1.1) | 36 (77) | 5 (38) | 6 (46) | 1 (8) |
| t(6;11) | 8 (0.7) | 46 (100) | 5 (63) | 1 (13) | 0 (0) |
| t(11;19)(q23;p13.1) | 6 (0.5) | 57 (50) | 5 (83) | 0 (0) | 0 (0) |
| −20/20q− | 39 (3.2) | 60 (44) | 6 (15) | 29 (74) | 28 (72) |
| del(20q) | 16 (1.3) | 65 (44) | 5 (31) | 9 (56) | 8 (50) |
| −20 | 15 (1.2) | 60 (47) | 1 (7) | 12 (80) | 12 (80) |
| Loss of 20q | 8 (0.7) | 61 (38) | 0 (0) | 8 (100) | 8 (100) |
| del(9q) | 33 (2.7) | 37 (82) | 11 (33) | 10 (30) | 2 (6) |
| abn(12p) | 33 (2.7) | 64 (36) | 1 (3) | 25 (76) | 21 (64) |
| Unbalanced abn(12p) | 25 (2.1) | 64 (32) | 1 (4) | 20 (80) | 16 (64) |
| Balanced abn(12p) | 8 (0.7) | 61 (50) | 0 (0) | 5 (63) | 5 (63) |
| +22 | 31 (2.6) | 59 (55) | 1 (3) | 19 (61) | 14 (45) |
| −18 | 30 (2.5) | 64 (30) | 1 (3) | 29 (97) | 28 (93) |
| +13 | 29 (2.4) | 59 (55) | 13 (45) | 12 (41) | 10 (34) |
| +21 | 28 (2.3) | 59 (54) | 5 (24) | 14 (50) | 10 (36) |
| +11 | 20 (1.6) | 65 (20) | 12 (60) | 7 (35) | 6 (30) |
| −X | 18 (1.5) | 44 (67) | 0 (0) | 8 (44) | 5 (28) |
| +4 | 14 (1.2) | 55 (57) | 2 (14) | 10 (71) | 6 (43) |
| +14 | 12 (1.0) | 64 (42) | 0 (0) | 10 (83) | 9 (75) |
| del(11q) | 12 (1.0) | 42 (58) | 4 (33) | 5 (42) | 3 (25) |
| inv(3) or t(3;3) | 12 (1.0) | 43 (83) | 2 (17) | 4 (33) | 1 (8) |
| del(13q) | 9 (0.7) | 44 (56) | 1 (11) | 7 (78) | 5 (56) |
| t(6;9) | 8 (0.7) | 33 (100) | 6 (75) | 0 (0) | 0 (0) |
NA indicates not applicable.
v denotes various chromosomes (other than chromosomes 6, 9, and 19 with a break at p13.1) participating in translocations with chromosome 11 at band q23.