Table 1. Variables before defibrotide... | American Society of Hematology

Table 1.

Variables before defibrotide (DF) treatment and day +100 survival (univariate analysis; N = 88)

	n	Day + 100 survival, %	P
Patient characteristics
Age, y
Younger than 18	29	51.7	.033^*
18 or older	59	27.1
Sex
Female	41	31.7	.655
Male	47	38.3
Diagnosis
Nonmalignant	8	50	.001^*
Hematologic malignancy	63	23.8
Nonhematologic malignancy	17	70.6
Graft
Auto	28	53.6	.018^*
Allo	60	26.7
No. BMT
More than 1	14	50	.233
1	74	32.4
AST elevation preconditioning
No	69	34.8	1.000
Yes	19	36.8
Conditioning regimen
Cy
No	22	27.3	.446
Yes	66	37.9
Bu
No	41	48.8	.015^*
Yes	47	23.4
TBI
No	59	33.9	.813
Yes	29	37.9
Characteristics of VOD
RUQ pain
No	18	27.8	.584
Yes	70	37.1
Ascites
No	14	28.6	.762
Yes	74	36.5
Hepatomegaly
No	24	25	.317
Yes	64	37.5
Portal flow
Normal	57	28.1	.066
Abnormal	31	48.4
Prior t-PA/heparin
No	74	29.7	.029^*
Yes	14	64.3
Abnormal creatinine
No	23	39.1	.800
Yes	65	33.8
Oxygen requiring
No	24	50	.086
Yes	64	29.7
Encephalopathy
No	56	41.1	.166
Yes	32	25
No. of systems as part of MOF (liver + renal + pulmonary + CNS)
2 or fewer	30	46.7	.065
More than 2	58	29.3

	n	Day + 100 survival, %	P
Patient characteristics
Age, y
Younger than 18	29	51.7	.033^*
18 or older	59	27.1
Sex
Female	41	31.7	.655
Male	47	38.3
Diagnosis
Nonmalignant	8	50	.001^*
Hematologic malignancy	63	23.8
Nonhematologic malignancy	17	70.6
Graft
Auto	28	53.6	.018^*
Allo	60	26.7
No. BMT
More than 1	14	50	.233
1	74	32.4
AST elevation preconditioning
No	69	34.8	1.000
Yes	19	36.8
Conditioning regimen
Cy
No	22	27.3	.446
Yes	66	37.9
Bu
No	41	48.8	.015^*
Yes	47	23.4
TBI
No	59	33.9	.813
Yes	29	37.9
Characteristics of VOD
RUQ pain
No	18	27.8	.584
Yes	70	37.1
Ascites
No	14	28.6	.762
Yes	74	36.5
Hepatomegaly
No	24	25	.317
Yes	64	37.5
Portal flow
Normal	57	28.1	.066
Abnormal	31	48.4
Prior t-PA/heparin
No	74	29.7	.029^*
Yes	14	64.3
Abnormal creatinine
No	23	39.1	.800
Yes	65	33.8
Oxygen requiring
No	24	50	.086
Yes	64	29.7
Encephalopathy
No	56	41.1	.166
Yes	32	25
No. of systems as part of MOF (liver + renal + pulmonary + CNS)
2 or fewer	30	46.7	.065
More than 2	58	29.3

BMT indicates bone marrow transplantation; AST: aspartate transferase; and CNS, central nervous system.

Significant at .05 level.