CD38 expression in 29 B-CLL patients sequentially evaluated
| Case no. . | First determination, % . | Time between the 2 determinations, mo . | Last determination, % . | Disease status at last determination . |
|---|---|---|---|---|
| 1 | 8 | 41 | 10 | PBLC increased, Rai stage shift from 0 to I |
| 2 | 1 | 16 | 2 | PBLC increased, Herpes zoster |
| 3 | 0.8 | 18 | 0.6 | Spontaneous spleen rupture, then stable disease with lymphocytosis only |
| 4 | 3 | 40 | 7 | PBLC increased, Rai stage shift from I to IV |
| 5 | 1 | 36 | 0.2 | PBLC increased, Rai stage 0 |
| 6 | 1 | 23 | 2 | Rai stage II, broncopneumonia |
| 7 | 14 | 10 | 15 | Relapse after fludarabine-based regimen therapy, Rai stage IV |
| 8 | 13 | 6 | 16 | Rai stage I, stable |
| 9 | 4 | 18 | 1 | Rai stage 0, PBLC increased |
| 10 | 2.6 | 10 | 0.5 | Rai stage 0, stable |
| 11 | 1 | 12 | 0.7 | Rai stage I, stable |
| 12 | 4.1 | 2 | 4.1 | Rai stage IV, acute renal failure* |
| 13 | 30 | 9 | 37 | Rai stage I, stable |
| 14 | 90 | 13 | 88 | Rai stage I, stable |
| 15 | 19 | 14 | 12 | Rai stage II, PBLC increased |
| 16 | 7 | 8 | 6 | Rai stage I, PBLC increased |
| 17 | 4 | 12 | 6 | Rai stage I, stable |
| 18 | 0.7 | 4 | 0.7 | Rai stage 0, stable |
| 19 | 57 | 6 | 58 | Rai stage I, stable |
| 20 | 69 | 12 | 72 | Rai stage I, stable |
| 21 | 54 | 18 | 49 | Rai stage IV, progression after several lines of therapy |
| 22 | 7 | 12 | 6 | Rai stage 0, gastric cancer |
| 23 | 10 | 20 | 14 | Rai stage 0, stable |
| 24 | 1 | 8 | 2 | Rai stage I, stable |
| 25 | 0.1 | 40 | 0.1 | Rai stage 0, stable |
| 26 | 0.5 | 6 | 0.5 | Rai stage IV, stable |
| 27 | 45 | 18 | 43 | Rai stage II, stable |
| 28 | 0.9 | 39 | 1.2 | Rai stage 0, stable |
| 29 | 1.3 | 22 | 0.8 | Rai stage 0, stable |
| Case no. . | First determination, % . | Time between the 2 determinations, mo . | Last determination, % . | Disease status at last determination . |
|---|---|---|---|---|
| 1 | 8 | 41 | 10 | PBLC increased, Rai stage shift from 0 to I |
| 2 | 1 | 16 | 2 | PBLC increased, Herpes zoster |
| 3 | 0.8 | 18 | 0.6 | Spontaneous spleen rupture, then stable disease with lymphocytosis only |
| 4 | 3 | 40 | 7 | PBLC increased, Rai stage shift from I to IV |
| 5 | 1 | 36 | 0.2 | PBLC increased, Rai stage 0 |
| 6 | 1 | 23 | 2 | Rai stage II, broncopneumonia |
| 7 | 14 | 10 | 15 | Relapse after fludarabine-based regimen therapy, Rai stage IV |
| 8 | 13 | 6 | 16 | Rai stage I, stable |
| 9 | 4 | 18 | 1 | Rai stage 0, PBLC increased |
| 10 | 2.6 | 10 | 0.5 | Rai stage 0, stable |
| 11 | 1 | 12 | 0.7 | Rai stage I, stable |
| 12 | 4.1 | 2 | 4.1 | Rai stage IV, acute renal failure* |
| 13 | 30 | 9 | 37 | Rai stage I, stable |
| 14 | 90 | 13 | 88 | Rai stage I, stable |
| 15 | 19 | 14 | 12 | Rai stage II, PBLC increased |
| 16 | 7 | 8 | 6 | Rai stage I, PBLC increased |
| 17 | 4 | 12 | 6 | Rai stage I, stable |
| 18 | 0.7 | 4 | 0.7 | Rai stage 0, stable |
| 19 | 57 | 6 | 58 | Rai stage I, stable |
| 20 | 69 | 12 | 72 | Rai stage I, stable |
| 21 | 54 | 18 | 49 | Rai stage IV, progression after several lines of therapy |
| 22 | 7 | 12 | 6 | Rai stage 0, gastric cancer |
| 23 | 10 | 20 | 14 | Rai stage 0, stable |
| 24 | 1 | 8 | 2 | Rai stage I, stable |
| 25 | 0.1 | 40 | 0.1 | Rai stage 0, stable |
| 26 | 0.5 | 6 | 0.5 | Rai stage IV, stable |
| 27 | 45 | 18 | 43 | Rai stage II, stable |
| 28 | 0.9 | 39 | 1.2 | Rai stage 0, stable |
| 29 | 1.3 | 22 | 0.8 | Rai stage 0, stable |
PBLC indicates peripheral blood lymphocyte count.
Patient underwent hemodialysis when PBLC was 90 000/μL. During the procedure the PBLC decreased to 10 000/μL and after renal function recovery increased to 17 000/μL. All 5 determinations of CD19+CD38+ B cells ranged from 3.8% to 4.1%.