EVI1, MDS1-EVI1, andMDS1 expression in 7 AML patients with 3q26 abnormalities
| Patient . | FAB . | Cytogenetic abnormalities3-150 . | Relative expression of EVI13-151 . | Relative expression ofMDS1-EVI13-151 . | Expression of MDS13-152 . |
|---|---|---|---|---|---|
| 1 | M5 | inv(3)(q22q26),−7 | 1 618 | 104 | − |
| 2 | M1 | inv(3)(q22q26) | 4 390 | 4 390 | − |
| 3 | M0 | inv(3)(q21q26) | 4 771 | 416 | − |
| 4 | M4 | t(3;3)(q22;q26) | 2 353 | 1 448 | − |
| 5 | RAEB-t | t(3;12)(q26;p13) | 1 951 | 35 | − |
| 6 | RAEB-t | t(3;12)(q25a26;p12), del(7)(q22) | 1 | 11 585 | + |
| 7 | CML | t(3;17)(q26;q22),t(1;17;9;22) (p36;q12;q34;q11)/del(11)(p11.1p14) | 30 | 1 | − |
| Patient . | FAB . | Cytogenetic abnormalities3-150 . | Relative expression of EVI13-151 . | Relative expression ofMDS1-EVI13-151 . | Expression of MDS13-152 . |
|---|---|---|---|---|---|
| 1 | M5 | inv(3)(q22q26),−7 | 1 618 | 104 | − |
| 2 | M1 | inv(3)(q22q26) | 4 390 | 4 390 | − |
| 3 | M0 | inv(3)(q21q26) | 4 771 | 416 | − |
| 4 | M4 | t(3;3)(q22;q26) | 2 353 | 1 448 | − |
| 5 | RAEB-t | t(3;12)(q26;p13) | 1 951 | 35 | − |
| 6 | RAEB-t | t(3;12)(q25a26;p12), del(7)(q22) | 1 | 11 585 | + |
| 7 | CML | t(3;17)(q26;q22),t(1;17;9;22) (p36;q12;q34;q11)/del(11)(p11.1p14) | 30 | 1 | − |
According to the ISCN.22
Values represent expression levels of EVI1 andMDS1-EVI1 as compared with the average values determined in 9 healthy bone marrow samples 2−δ δCt(see “Patients, materials, and methods”).
MDS1 expression was considered positive (+) when the Ct value was below 35.