MCL patients with mutated VH genes
| MCL patient . | Morphology . | VHgene . | No.mutations . | Homology, % . | D . | JH . | Frame . | Ongoing mutation . | Germline analyzed . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MCL-BV | VH3-23 | 7 | 96.9 | D2-15 | JH1-6 | IF | — | — |
| 10 | MCL | VH3-23 | 8 | 95.3 | D1-7+D5-12 | JH4 | IF | — | — |
| 11 | MCL-BV | VH4-34 | 5 | 97.7 | D1-26 | JH4 | IF | — | — |
| 20 | MCL | VH4-34 | 5 | 97.7 | D6-19 rev | JH6 | IF | — | — |
| 22 | MCL | VH3-33 | 5 | 97.8 | D1-26 | JH4 | IF | — | — |
| 37 | MCL | VH4-59 | 6 | 97.3 | D6-13 | JH4 | IF | — | Yes |
| 413-150 | MCL | VH4-30 | 7 | 96.9 | ND | JH3 | IF | — | — |
| 45 | MCL | VH3-72 | 5 | 97.8 | D1-20/D1-7 | JH4 | IF | — | Yes |
| 46 | MCL | VH4-34 | 6 | 97.3 | ND | JH6 | IF | No | Yes |
| 51 | MCL | VH3-23 | 6 | 97.3 | D4-23 | JH4 | IF | No | Yes |
| 59 | MCL | VH3-48 | 5 | 97.8 | ND | JH6 | IF | — | — |
| 603-150 | MCL | VH4-31 | 5 | 97.8 | D4-17 | JH4 | SC | — | — |
| 65 | MCL | VH1-8 | 7 | 96.8 | ND | JH1-6 | IF | — | — |
| 70 | MCL | VH3-30 | 6 | 97.3 | D6-19 | JH4 | IF | No | — |
| 75 | MCL-BV | VH3-30 | 15 | 93.3 | D6-13 | JH4 | IF | No | — |
| 873-150 | MCL | VH4-34 | 10 | 95.4 | D6-19 | JH2 | IF | — | — |
| 89 | MCL | VH3-74 | 8 | 96.4 | D7-27 | JH5 | IF | No | Yes |
| 99 | MCL-BV | VH3-74 | 5 | 97.8 | D6-13 | JH3 | IF | — | — |
| MCL patient . | Morphology . | VHgene . | No.mutations . | Homology, % . | D . | JH . | Frame . | Ongoing mutation . | Germline analyzed . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MCL-BV | VH3-23 | 7 | 96.9 | D2-15 | JH1-6 | IF | — | — |
| 10 | MCL | VH3-23 | 8 | 95.3 | D1-7+D5-12 | JH4 | IF | — | — |
| 11 | MCL-BV | VH4-34 | 5 | 97.7 | D1-26 | JH4 | IF | — | — |
| 20 | MCL | VH4-34 | 5 | 97.7 | D6-19 rev | JH6 | IF | — | — |
| 22 | MCL | VH3-33 | 5 | 97.8 | D1-26 | JH4 | IF | — | — |
| 37 | MCL | VH4-59 | 6 | 97.3 | D6-13 | JH4 | IF | — | Yes |
| 413-150 | MCL | VH4-30 | 7 | 96.9 | ND | JH3 | IF | — | — |
| 45 | MCL | VH3-72 | 5 | 97.8 | D1-20/D1-7 | JH4 | IF | — | Yes |
| 46 | MCL | VH4-34 | 6 | 97.3 | ND | JH6 | IF | No | Yes |
| 51 | MCL | VH3-23 | 6 | 97.3 | D4-23 | JH4 | IF | No | Yes |
| 59 | MCL | VH3-48 | 5 | 97.8 | ND | JH6 | IF | — | — |
| 603-150 | MCL | VH4-31 | 5 | 97.8 | D4-17 | JH4 | SC | — | — |
| 65 | MCL | VH1-8 | 7 | 96.8 | ND | JH1-6 | IF | — | — |
| 70 | MCL | VH3-30 | 6 | 97.3 | D6-19 | JH4 | IF | No | — |
| 75 | MCL-BV | VH3-30 | 15 | 93.3 | D6-13 | JH4 | IF | No | — |
| 873-150 | MCL | VH4-34 | 10 | 95.4 | D6-19 | JH2 | IF | — | — |
| 89 | MCL | VH3-74 | 8 | 96.4 | D7-27 | JH5 | IF | No | Yes |
| 99 | MCL-BV | VH3-74 | 5 | 97.8 | D6-13 | JH3 | IF | — | — |
Ongoing mutation was investigated by subcloning in the cases indicated. Unrearranged germline genes were analyzed from T cells of the 5 patients noted.
A second rearrangement was also detected.
MCL-BV indicates blastoid variant; IF, in-frame rearrangement; SC, rearrangement with stop codon; ND, not able to define; and —, not analyzed.