Genetic comparison between WM, myeloma, and B-CLL
| Feature . | WM . | Myeloma . | B-CLL . |
|---|---|---|---|
| Clinical course | Usually indolent | Aggressive | Usually indolent |
| Genomic stability (ploidy) | Diploid | Aneuploid | Diploid |
| Structural abnormalities (other than 6q) | Infrequent | Frequent, multiple | Infrequent |
| IgH translocations | Rare | 75% | Rare |
| Chromosome 13 abnormalities at diagnosis | Rare28 | ∼50% | ∼50% |
| Deletions of 17p13 | Rare at diagnosis28 | Rare (10%-15%) | Rare (5%) |
| Proliferation by the labeling index | Low/absent | Active | Not done |
| Somatic hypermutation | Yes | Yes | Variable |
| Feature . | WM . | Myeloma . | B-CLL . |
|---|---|---|---|
| Clinical course | Usually indolent | Aggressive | Usually indolent |
| Genomic stability (ploidy) | Diploid | Aneuploid | Diploid |
| Structural abnormalities (other than 6q) | Infrequent | Frequent, multiple | Infrequent |
| IgH translocations | Rare | 75% | Rare |
| Chromosome 13 abnormalities at diagnosis | Rare28 | ∼50% | ∼50% |
| Deletions of 17p13 | Rare at diagnosis28 | Rare (10%-15%) | Rare (5%) |
| Proliferation by the labeling index | Low/absent | Active | Not done |
| Somatic hypermutation | Yes | Yes | Variable |