Presenting features of children with standard risk acute lymphoblastic leukemia
| . | OP (N = 270) . | IP (N = 260) . | OD (N = 274) . | ID (N = 256) . | P* . | ||||
|---|---|---|---|---|---|---|---|---|---|
| N . | (%) . | N . | (%) . | N . | (%) . | N . | (%) . | ||
| Age, y | .84 | ||||||||
| 1 to less than 2 | 24 | (9) | 20 | (8) | 26 | (10) | 20 | (8) | |
| 2 to less than 4 | 120 | (44) | 108 | (42) | 108 | (40) | 115 | (45) | |
| 4 to less than 10 | 126 | (47) | 131 | (50) | 140 | (51) | 121 | (47) | |
| WBC count, × 109/L | .71 | ||||||||
| Below 20 | 230 | (85) | 220 | (85) | 226 | (83) | 210 | (82) | |
| 20-49 | 40 | (15) | 40 | (15) | 48 | (18) | 46 | (18) | |
| Gender | .25 | ||||||||
| Male | 136 | (50) | 145 | (56) | 148 | (54) | 122 | (48) | |
| Female | 134 | (50) | 115 | (44) | 126 | (46) | 134 | (52) | |
| Race | .23 | ||||||||
| White | 195 | (76) | 190 | (76) | 213 | (79) | 197 | (79) | |
| Black | 14 | (5) | 10 | (4) | 13 | (5) | 11 | (4) | |
| Hispanic | 39 | (15) | 43 | (17) | 30 | (11) | 37 | (15) | |
| Other | 9 | (4) | 8 | (3) | 15 | (6) | 3 | (1) | |
| Down syndrome | .25 | ||||||||
| Yes | 7 | (3) | 1 | (0) | 5 | (2) | 5 | (2) | |
| No | 263 | (97) | 258 | (100) | 269 | (98) | 251 | (98) | |
| Liver† | .50 | ||||||||
| Normal | 133 | (49) | 143 | (55) | 144 | (53) | 124 | (49) | |
| Moderately enlarged | 130 | (48) | 107 | (41) | 119 | (43) | 125 | (49) | |
| Markedly enlarged | 7 | (7) | 9 | (4) | 11 | (4) | 6 | (2) | |
| Spleen† | .62 | ||||||||
| Normal | 151 | (56) | 164 | (64) | 162 | (59) | 152 | (60) | |
| Moderately enlarged | 110 | (41) | 285 | (33) | 105 | (38) | 93 | (37) | |
| Markedly enlarged | 9 | (3) | 9 | (4) | 7 | (3) | 10 | (4) | |
| Lymph nodes‡ | .25 | ||||||||
| Normal | 144 | (53) | 159 | (61) | 148 | (54) | 149 | (58) | |
| Moderately enlarged | 122 | (45) | 98 | (38) | 119 | (43) | 100 | (39) | |
| Markedly enlarged | 4 | (2) | 2 | (2) | 7 | (3) | 7 | (3) | |
| Mediastinal mass | .05 | ||||||||
| Absent | 247 | (92) | 249 | (96) | 260 | (95) | 232 | (93) | |
| Present | 23 | (9) | 11 | (4) | 14 | (5) | 24 | (7) | |
| Hemoglobin level, g/dL | .36 | ||||||||
| 1-7.9 | 178 | (66) | 153 | (60) | 180 | (67) | 170 | (67) | |
| 8.0-10.9 | 80 | (30) | 85 | (33) | 74 | (28) | 71 | (28) | |
| 11.0 or above | 10 | (4) | 19 | (7) | 14 | (5) | 13 | (5) | |
| Platelet count, × 109/L | .24 | ||||||||
| 1-49 | 138 | (51) | 105 | (41) | 125 | (46) | 125 | (49) | |
| 50-149 | 72 | (27) | 90 | (35) | 90 | (33) | 80 | (31) | |
| 150 or above | 60 | (22) | 64 | (25) | 59 | (22) | 51 | (20) | |
| CNS disease at diagnosis | .11 | ||||||||
| Yes | 0 | (0) | 5 | (2) | 5 | (2) | 2 | (1) | |
| No | 269 | (100) | 249 | (98) | 263 | (98) | 252 | (99) | |
| Immunophenotype | .10 | ||||||||
| B lineage | 133 | (99) | 143 | (97) | 148 | (97) | 121 | (93) | |
| T lineage | 2 | (2) | 4 | (3) | 5 | (3) | 9 | (7) | |
| Ploidy group | .74 | ||||||||
| Normal | 28 | (32) | 31 | (33) | 40 | (39) | 28 | (30) | |
| Pseudodiploid | 7 | (8) | 3 | (3) | 6 | (6) | 6 | (7) | |
| Hypodiploid | 17 | (19) | 19 | (20) | 21 | (20) | 23 | (25) | |
| Hyperdiploid (47-50) | 5 | (6) | 8 | (9) | 10 | (10) | 11 | (12) | |
| Hyperdiploid (>50) | 31 | (35) | 32 | (34) | 26 | (25) | 24 | (26) | |
| t(4;11)(q21;q23) | |||||||||
| Yes | 1 | (1) | 0 | (0) | 0 | (0) | 0 | (0) | |
| No | 87 | (99) | 93 | (100) | 103 | (100) | 92 | (100) | |
| t(9;22)(q34;q11) | |||||||||
| Yes | 3 | (3) | 1 | (1) | 1 | (1) | 1 | (0) | |
| No | 85 | (97) | 92 | (99) | 102 | (99) | 91 | (100) | |
| t(1;19)(q23;p13) | |||||||||
| Yes | 1 | (1) | 1 | (1) | 3 | (3) | 3 | (3) | |
| No | 87 | (99) | 92 | (99) | 100 | (97) | 89 | (97) | |
| . | OP (N = 270) . | IP (N = 260) . | OD (N = 274) . | ID (N = 256) . | P* . | ||||
|---|---|---|---|---|---|---|---|---|---|
| N . | (%) . | N . | (%) . | N . | (%) . | N . | (%) . | ||
| Age, y | .84 | ||||||||
| 1 to less than 2 | 24 | (9) | 20 | (8) | 26 | (10) | 20 | (8) | |
| 2 to less than 4 | 120 | (44) | 108 | (42) | 108 | (40) | 115 | (45) | |
| 4 to less than 10 | 126 | (47) | 131 | (50) | 140 | (51) | 121 | (47) | |
| WBC count, × 109/L | .71 | ||||||||
| Below 20 | 230 | (85) | 220 | (85) | 226 | (83) | 210 | (82) | |
| 20-49 | 40 | (15) | 40 | (15) | 48 | (18) | 46 | (18) | |
| Gender | .25 | ||||||||
| Male | 136 | (50) | 145 | (56) | 148 | (54) | 122 | (48) | |
| Female | 134 | (50) | 115 | (44) | 126 | (46) | 134 | (52) | |
| Race | .23 | ||||||||
| White | 195 | (76) | 190 | (76) | 213 | (79) | 197 | (79) | |
| Black | 14 | (5) | 10 | (4) | 13 | (5) | 11 | (4) | |
| Hispanic | 39 | (15) | 43 | (17) | 30 | (11) | 37 | (15) | |
| Other | 9 | (4) | 8 | (3) | 15 | (6) | 3 | (1) | |
| Down syndrome | .25 | ||||||||
| Yes | 7 | (3) | 1 | (0) | 5 | (2) | 5 | (2) | |
| No | 263 | (97) | 258 | (100) | 269 | (98) | 251 | (98) | |
| Liver† | .50 | ||||||||
| Normal | 133 | (49) | 143 | (55) | 144 | (53) | 124 | (49) | |
| Moderately enlarged | 130 | (48) | 107 | (41) | 119 | (43) | 125 | (49) | |
| Markedly enlarged | 7 | (7) | 9 | (4) | 11 | (4) | 6 | (2) | |
| Spleen† | .62 | ||||||||
| Normal | 151 | (56) | 164 | (64) | 162 | (59) | 152 | (60) | |
| Moderately enlarged | 110 | (41) | 285 | (33) | 105 | (38) | 93 | (37) | |
| Markedly enlarged | 9 | (3) | 9 | (4) | 7 | (3) | 10 | (4) | |
| Lymph nodes‡ | .25 | ||||||||
| Normal | 144 | (53) | 159 | (61) | 148 | (54) | 149 | (58) | |
| Moderately enlarged | 122 | (45) | 98 | (38) | 119 | (43) | 100 | (39) | |
| Markedly enlarged | 4 | (2) | 2 | (2) | 7 | (3) | 7 | (3) | |
| Mediastinal mass | .05 | ||||||||
| Absent | 247 | (92) | 249 | (96) | 260 | (95) | 232 | (93) | |
| Present | 23 | (9) | 11 | (4) | 14 | (5) | 24 | (7) | |
| Hemoglobin level, g/dL | .36 | ||||||||
| 1-7.9 | 178 | (66) | 153 | (60) | 180 | (67) | 170 | (67) | |
| 8.0-10.9 | 80 | (30) | 85 | (33) | 74 | (28) | 71 | (28) | |
| 11.0 or above | 10 | (4) | 19 | (7) | 14 | (5) | 13 | (5) | |
| Platelet count, × 109/L | .24 | ||||||||
| 1-49 | 138 | (51) | 105 | (41) | 125 | (46) | 125 | (49) | |
| 50-149 | 72 | (27) | 90 | (35) | 90 | (33) | 80 | (31) | |
| 150 or above | 60 | (22) | 64 | (25) | 59 | (22) | 51 | (20) | |
| CNS disease at diagnosis | .11 | ||||||||
| Yes | 0 | (0) | 5 | (2) | 5 | (2) | 2 | (1) | |
| No | 269 | (100) | 249 | (98) | 263 | (98) | 252 | (99) | |
| Immunophenotype | .10 | ||||||||
| B lineage | 133 | (99) | 143 | (97) | 148 | (97) | 121 | (93) | |
| T lineage | 2 | (2) | 4 | (3) | 5 | (3) | 9 | (7) | |
| Ploidy group | .74 | ||||||||
| Normal | 28 | (32) | 31 | (33) | 40 | (39) | 28 | (30) | |
| Pseudodiploid | 7 | (8) | 3 | (3) | 6 | (6) | 6 | (7) | |
| Hypodiploid | 17 | (19) | 19 | (20) | 21 | (20) | 23 | (25) | |
| Hyperdiploid (47-50) | 5 | (6) | 8 | (9) | 10 | (10) | 11 | (12) | |
| Hyperdiploid (>50) | 31 | (35) | 32 | (34) | 26 | (25) | 24 | (26) | |
| t(4;11)(q21;q23) | |||||||||
| Yes | 1 | (1) | 0 | (0) | 0 | (0) | 0 | (0) | |
| No | 87 | (99) | 93 | (100) | 103 | (100) | 92 | (100) | |
| t(9;22)(q34;q11) | |||||||||
| Yes | 3 | (3) | 1 | (1) | 1 | (1) | 1 | (0) | |
| No | 85 | (97) | 92 | (99) | 102 | (99) | 91 | (100) | |
| t(1;19)(q23;p13) | |||||||||
| Yes | 1 | (1) | 1 | (1) | 3 | (3) | 3 | (3) | |
| No | 87 | (99) | 92 | (99) | 100 | (97) | 89 | (97) | |