Observed cancers, ratio of observed to expected cancers, and 95% CIs among North American respondents with FA
| . | No. of observed cancers* . | O/E† . | 95% CI‡ . |
|---|---|---|---|
| Cancer type | |||
| Leukemia (AML) | 9 | 7852-153 | 360-1490 |
| Head and neck | 6 | 7062-153 | 260-1540 |
| Esophagus | 2 | 23622-153 | 265-8530 |
| Liver | 2 | 3862-153 | 45-1395 |
| Vulva | 3 | 43172-153 | 870-12 615 |
| Cervix | 2 | 1792-153 | 20-645 |
| Osteosarcoma | 1 | 79 | 1-440 |
| Soft-tissue sarcoma | 1 | 49 | 0.6-270 |
| Brain | 1 | 17 | 0.2-95 |
| Total cancers | 27 | 502-153 | 35-80 |
| Total solid tumors | 18 | 482-153 | 30-80 |
| . | No. of observed cancers* . | O/E† . | 95% CI‡ . |
|---|---|---|---|
| Cancer type | |||
| Leukemia (AML) | 9 | 7852-153 | 360-1490 |
| Head and neck | 6 | 7062-153 | 260-1540 |
| Esophagus | 2 | 23622-153 | 265-8530 |
| Liver | 2 | 3862-153 | 45-1395 |
| Vulva | 3 | 43172-153 | 870-12 615 |
| Cervix | 2 | 1792-153 | 20-645 |
| Osteosarcoma | 1 | 79 | 1-440 |
| Soft-tissue sarcoma | 1 | 49 | 0.6-270 |
| Brain | 1 | 17 | 0.2-95 |
| Total cancers | 27 | 502-153 | 35-80 |
| Total solid tumors | 18 | 482-153 | 30-80 |
A total of 27 cancers observed in 23 patients (Table 1). Two patients had 2 solid tumors (cervix and vulva, and vulva and esophagus) and 1 patient had 3 solid tumors (esophagus, liver, and cervix).
Expected cancer incidence rates calculated from the Connecticut Tumor Registry.
Limits of the 95% CIs rounded to the nearest 5 for values greater than or equal to 10.
P < .05 that true O/E ratio equals 1.0 (exact 2-sided tests).