Table 1. Plasma levels of Hcy, NEFA, TC,... | American Society of Hematology

Table 1.

Plasma levels of Hcy, NEFA, TC, and TG

Genotype	No.	Hcy, μM	NEFA, mEq/L	TC, mg/dL	TG, mg/dL
Regular diet
CBS^+/+/ApoE^−/−	14	3.8 ± 0.9	0.74 ± 0.42	387 ± 130	128 ± 64
CBS^−/+/ApoE^−/−	15	7.4 ± 2.9	0.73 ± 0.12	442 ± 111	145 ± 56
CBS^−/−/ApoE^−/−	12	210.4 ± 80.1	0.83 ± 0.03	559 ± 84	72 ± 21
		P < .001^*,^†		P < .001^*	P = .009^*
				P = .006^†	P < .001^†
High-fat diet
CBS^+/+/ApoE^−/−	12	5.9 ± 2.0	1.37 ± 0.35	1271 ± 233	166 ± 40
		P = .039^*	P = .099^*	P < .001^*	P = .095^*
CBS^−/+/ApoE^−/−	12	14.2 ± 7.8	1.61 ± 0.54	1366 ± 303	259 ± 166
		P = .011^†	P = .029^†	P < .001^†	P = .02^†
High-fat plus high-methionine diet
CBS^−/+/ApoE^−/−	14	154.9 ± 90.7	1.10 ± 0.27	1545 ± 264	162 ± 89
		P < .001^‡

Genotype	No.	Hcy, μM	NEFA, mEq/L	TC, mg/dL	TG, mg/dL
Regular diet
CBS^+/+/ApoE^−/−	14	3.8 ± 0.9	0.74 ± 0.42	387 ± 130	128 ± 64
CBS^−/+/ApoE^−/−	15	7.4 ± 2.9	0.73 ± 0.12	442 ± 111	145 ± 56
CBS^−/−/ApoE^−/−	12	210.4 ± 80.1	0.83 ± 0.03	559 ± 84	72 ± 21
		P < .001^*,^†		P < .001^*	P = .009^*
				P = .006^†	P < .001^†
High-fat diet
CBS^+/+/ApoE^−/−	12	5.9 ± 2.0	1.37 ± 0.35	1271 ± 233	166 ± 40
		P = .039^*	P = .099^*	P < .001^*	P = .095^*
CBS^−/+/ApoE^−/−	12	14.2 ± 7.8	1.61 ± 0.54	1366 ± 303	259 ± 166
		P = .011^†	P = .029^†	P < .001^†	P = .02^†
High-fat plus high-methionine diet
CBS^−/+/ApoE^−/−	14	154.9 ± 90.7	1.10 ± 0.27	1545 ± 264	162 ± 89
		P < .001^‡

Mice were grown under regular diet or fed an HF or an HF + HM diet at 8 weeks of age for 3 months. Values are mean ± SD; P values from t test. Only significant P values are shown.

Hcy indicates homocysteine; NEFA, nonesterified fatty acid; TC, total cholesterol; and TG, triglyceride.

Comparison versus CBS^+/+/ApoE^−/−.

†

Comparison versus CBS^−/+/ApoE^−/−.

‡

Comparison versus CBS^−/+/ApoE^−/− on high-fat diet.

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