The course of C4 and albumin serum levels in the studied patients after rituximab therapy
. | Median value . | Increase less than 25% or unchanged . | Increase 25% or greater . | Normalization . | Notes . | |||||
---|---|---|---|---|---|---|---|---|---|---|
Months | 0 | +3 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | — |
C4 mg/dL | 2 | 85-150 | 85-150 | 6 of 14 | 7 of 14 | 3 of 14 | 3 of 14 | 5 of 14 | 4 of 14 | Normalized at month +6 in patients 3, 4, 14, 15 |
Albumin g/L | 3.7 | 3.95-150 | 4.05-150 | 12 of 15 | 14 of 15 | 0 of 15 | 0 of 15 | 3 of 15 | 1 of 15 | Normalized in patients 5 (+3 and +6) and 1, 11 (+3) |
. | Median value . | Increase less than 25% or unchanged . | Increase 25% or greater . | Normalization . | Notes . | |||||
---|---|---|---|---|---|---|---|---|---|---|
Months | 0 | +3 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | — |
C4 mg/dL | 2 | 85-150 | 85-150 | 6 of 14 | 7 of 14 | 3 of 14 | 3 of 14 | 5 of 14 | 4 of 14 | Normalized at month +6 in patients 3, 4, 14, 15 |
Albumin g/L | 3.7 | 3.95-150 | 4.05-150 | 12 of 15 | 14 of 15 | 0 of 15 | 0 of 15 | 3 of 15 | 1 of 15 | Normalized in patients 5 (+3 and +6) and 1, 11 (+3) |
— indicates not applicable; C4, complement fraction (decreased if < 10 mg/dL); albumin, low at baseline (<3.5 g/L) in 4 of 15 patients (patients 1, 5, 8, and 11).
P ≤ .05.