Adult human BM contains functional B-lineage precursors that can be enumerated in limiting dilution cultures of CD34+CD38− cells
| Source of CD34+CD38−cells . | Clonogenic frequency, % (CI) . | Frequency of cells able to give rise to CD19+ cells, % (CI) . |
|---|---|---|
| CB | 12.5 (11.11-14.29) | 6.67 (5.56-8.33) |
| Adult BM, 24 y | 6.09 (4.84-13.53) | 1.16 (0.77-1.96) |
| Adult BM, 44 y | 9.78 (7.78-19.01) | 1.04 (0.67-1.79) |
| Adult BM, 45 y | 3.69 (2.78-6.56) | 0.05 (<0.01-0.12) |
| Adult BM, 70 y | 4.5 (3.82-8.83) | 0.18 (0.07-0.31) |
| Adult BM, 88 y | 3.6 (3.24-4.26) | 0.15 (0.02-0.32) |
| Source of CD34+CD38−cells . | Clonogenic frequency, % (CI) . | Frequency of cells able to give rise to CD19+ cells, % (CI) . |
|---|---|---|
| CB | 12.5 (11.11-14.29) | 6.67 (5.56-8.33) |
| Adult BM, 24 y | 6.09 (4.84-13.53) | 1.16 (0.77-1.96) |
| Adult BM, 44 y | 9.78 (7.78-19.01) | 1.04 (0.67-1.79) |
| Adult BM, 45 y | 3.69 (2.78-6.56) | 0.05 (<0.01-0.12) |
| Adult BM, 70 y | 4.5 (3.82-8.83) | 0.18 (0.07-0.31) |
| Adult BM, 88 y | 3.6 (3.24-4.26) | 0.15 (0.02-0.32) |
CI indicates confidence interval.