Table 3. Granulocytopenia,... | American Society of Hematology

Table 3.

Granulocytopenia, granulocytopenic (WHO grade IV) fever requiring hospitalization and other toxicities (% of patients) in any cycle according to treatment group

Treatment group	Granulocytopenia, <0.5 × 10⁹/L	Granulocytopenic fever, <0.5 × 10⁹/L	Mucositis^3-150	GI toxicity^3-150	Alopecia^3-150	Cardiac toxicity^3-150,^3-151	Musculoskeletal pain^3-150
CHOP + G-CSF	55^3-152	34^3-152	5	15^3-153	80^3-155	5	10^3-154
CNOP + G-CSF	64^3-152	32^3-152	3	8	47	3	4^3-154
CHOP	89	50	4	10^3-153	81^3-155	3	2
CNOP	86	50	2	5	41	1	1

Treatment group	Granulocytopenia, <0.5 × 10⁹/L	Granulocytopenic fever, <0.5 × 10⁹/L	Mucositis^3-150	GI toxicity^3-150	Alopecia^3-150	Cardiac toxicity^3-150,^3-151	Musculoskeletal pain^3-150
CHOP + G-CSF	55^3-152	34^3-152	5	15^3-153	80^3-155	5	10^3-154
CNOP + G-CSF	64^3-152	32^3-152	3	8	47	3	4^3-154
CHOP	89	50	4	10^3-153	81^3-155	3	2
CNOP	86	50	2	5	41	1	1

GI indicates gastrointestinal.

F3-150

WHO grade III/IV.

F3-151

Patients with class I/II CHF (NYHA) excluded.

F3-152

P < .001 as compared to CHOP/CNOP.

F3-153

P < .05 as compared to CNOP with/without G-CSF.

F3-155

P < .001 as compared to CNOP with/without G-CSF.

F3-154

P < .01 as compared to CHOP/CNOP.

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