Table 6. Cycle-specific and cumulative... | American Society of Hematology

Table 6.

Cycle-specific and cumulative RDI of cyclophosphamide/doxorubicin and cyclophosphamide/mitoxantrone according to treatment group

Treatment group	Cycle no.
Treatment group	1	2	3	4	5	6	7	8
CHOP + G-CSF (n = 101)^6-150	87^6-151/100^6-152	70/92	66/88	61/84	61/83	55/77	53/71	51/68
Per cycle RDI, mean ± SD	96.5 ± 8.06	92.4 ± 11.40	94.6 ± 11.94	91.7 ± 13.67	92.6 ± 13.10	90.0 ± 16.91	90.2 ± 15.13	91.7 ± 13.42
Median	99.5	96.6	98.8	97.8	98.1	98.1	96.7	98.9
Cumulative RDI; mean ± SD	96.5 ± 8.06	94.1 ± 8.22	94.0 ± 7.62	93.2 ± 7.87	93.0 ± 8.12	92.3 ± 8.89	92.5 ± 9.24	92.6 ± 9.40
Median	99.5	97.6	96.7	95.5	96.0	95.5	95.9	96.3
CNOP + G-CSF (n = 125)^6-150	108^6-151/124^6-152	96/121	91/112	81/105	67/90	59/81	52/75	48/71
Per cycle RDI; mean ± SD	97.4 ± 9.07	94.3 ± 12.08	94.9 ± 14.94	94.0 ± 11.79	94.1 ± 12.75	92.5 ± 14.19	86.6 ± 17.12	92.1 ± 12.89
Median	99.5	99.1	99.0	99.0	99.1	99.0	95.7	98.9
Cumulative RDI; mean ± SD	97.4 ± 9.07	95.5 ± 8.43	95.2 ± 8.52	94.8 ± 8.39	94.7 ± 7.22	93.9 ± 7.73	92.4 ± 8.74	92.3 ± 8.68
Median	99.5	98.1	97.8	97.9	97.3	97.2	94.9	95.4
CHOP (n = 104)^6-150	91^6-151/102^6-152	71/96	70/89	59/85	54/80	46/77	41/72	37/66
Per cycle RDI; mean ± SD	97.9 ± 8.56	93.1 ± 11.45	92.0 ± 12.88	87.4 ± 15.62	87.8 ± 15.03	84.6 ± 19.31	82.4 ± 18.63	86.7 ± 15.13
Median	99.7	98.5	97.8	94.3	94.6	94.5	88.3	95.9
Cumulative RDI; mean ± SD	97.9 ± 8.56	95.2 ± 7.89	94.3 ± 8.05	92.5 ± 8.98	91.9 ± 8.75	90.3 ± 9.31	88.9 ± 10.14	88.8 ± 10.09
Median	99.7	98.3	97.3	94.6	94.1	92.9	91.7	90.9
CNOP (n = 125)^6-150	109^6-151/124^6-152	87/116	74/111	67/103	51/87	45/77	44/71	41/68
Per cycle RDI; mean ± SD	96.7 ± 9.01	92.1 ± 13.30	92.2 ± 14.68	90.0 ± 15.59	88.6 ± 17.34	87.0 ± 17.10	87.9 ± 16.19	86.3 ± 15.54
Median	99.1	99.1	98.9	98.7	97.3	97.3	97.0	96.0
Cumulative RDI; mean ± SD	96.7 ± 9.01	94.1 ± 9.26	93.0 ± 8.39	91.7 ± 8.97	90.78 ± 9.46	90.2 ± 9.99	90.3 ± 10.25	89.8 ± 10.17
Median	99.1	97.7	95.9	94.3	93.5	94.0	94.2	92.0

Treatment group	Cycle no.
Treatment group	1	2	3	4	5	6	7	8
CHOP + G-CSF (n = 101)^6-150	87^6-151/100^6-152	70/92	66/88	61/84	61/83	55/77	53/71	51/68
Per cycle RDI, mean ± SD	96.5 ± 8.06	92.4 ± 11.40	94.6 ± 11.94	91.7 ± 13.67	92.6 ± 13.10	90.0 ± 16.91	90.2 ± 15.13	91.7 ± 13.42
Median	99.5	96.6	98.8	97.8	98.1	98.1	96.7	98.9
Cumulative RDI; mean ± SD	96.5 ± 8.06	94.1 ± 8.22	94.0 ± 7.62	93.2 ± 7.87	93.0 ± 8.12	92.3 ± 8.89	92.5 ± 9.24	92.6 ± 9.40
Median	99.5	97.6	96.7	95.5	96.0	95.5	95.9	96.3
CNOP + G-CSF (n = 125)^6-150	108^6-151/124^6-152	96/121	91/112	81/105	67/90	59/81	52/75	48/71
Per cycle RDI; mean ± SD	97.4 ± 9.07	94.3 ± 12.08	94.9 ± 14.94	94.0 ± 11.79	94.1 ± 12.75	92.5 ± 14.19	86.6 ± 17.12	92.1 ± 12.89
Median	99.5	99.1	99.0	99.0	99.1	99.0	95.7	98.9
Cumulative RDI; mean ± SD	97.4 ± 9.07	95.5 ± 8.43	95.2 ± 8.52	94.8 ± 8.39	94.7 ± 7.22	93.9 ± 7.73	92.4 ± 8.74	92.3 ± 8.68
Median	99.5	98.1	97.8	97.9	97.3	97.2	94.9	95.4
CHOP (n = 104)^6-150	91^6-151/102^6-152	71/96	70/89	59/85	54/80	46/77	41/72	37/66
Per cycle RDI; mean ± SD	97.9 ± 8.56	93.1 ± 11.45	92.0 ± 12.88	87.4 ± 15.62	87.8 ± 15.03	84.6 ± 19.31	82.4 ± 18.63	86.7 ± 15.13
Median	99.7	98.5	97.8	94.3	94.6	94.5	88.3	95.9
Cumulative RDI; mean ± SD	97.9 ± 8.56	95.2 ± 7.89	94.3 ± 8.05	92.5 ± 8.98	91.9 ± 8.75	90.3 ± 9.31	88.9 ± 10.14	88.8 ± 10.09
Median	99.7	98.3	97.3	94.6	94.1	92.9	91.7	90.9
CNOP (n = 125)^6-150	109^6-151/124^6-152	87/116	74/111	67/103	51/87	45/77	44/71	41/68
Per cycle RDI; mean ± SD	96.7 ± 9.01	92.1 ± 13.30	92.2 ± 14.68	90.0 ± 15.59	88.6 ± 17.34	87.0 ± 17.10	87.9 ± 16.19	86.3 ± 15.54
Median	99.1	99.1	98.9	98.7	97.3	97.3	97.0	96.0
Cumulative RDI; mean ± SD	96.7 ± 9.01	94.1 ± 9.26	93.0 ± 8.39	91.7 ± 8.97	90.78 ± 9.46	90.2 ± 9.99	90.3 ± 10.25	89.8 ± 10.17
Median	99.1	97.7	95.9	94.3	93.5	94.0	94.2	92.0

F6-150

Number of patients randomized.

F6-151

Number of patients given 90% or more cumulatively according to protocol.

F6-152

Number of patients treated cumulatively according to protocol.

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