Adverse events in patients treated with G3139 and FLAG
| No. of patients with event of common toxicity criteria . | ||||
|---|---|---|---|---|
| Event . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
| Gastrointestinal | ||||
| Emesis | 10 | 3 | 0 | 0 |
| Diarrhea | 14 | 2 | 0 | 0 |
| Mucositis | 7 | 3 | 0 | 0 |
| Liver functions | ||||
| Total bilirubin | 2 | 2 | 3 | 1 |
| Transaminases | 6 | 1 | 0 | 0 |
| Alkaline phosphatase | 6 | 0 | 0 | 0 |
| Cardiovascular | ||||
| Chest pain | 1 | 1 | 0 | 0 |
| Dizziness | 2 | 2 | 2 | 0 |
| Hypertension | 2 | 0 | 0 | 0 |
| Hypotension | 2 | 1 | 0 | 1 |
| Respiratory | ||||
| Hypoxia | 0 | 0 | 12 | 1 |
| Dyspnea | 0 | 3 | 10 | 0 |
| Renal | ||||
| Increased creatinine level | 3 | 1 | 0 | 0 |
| Fluid retention | 11 | 3 | 1 | 0 |
| Electrolytes | ||||
| Hyponatremia | 3 | 1 | 2 | 0 |
| Hypokalemia | 4 | 1 | 9 | 2 |
| Hypocalcemia | 4 | 10 | 2 | 1 |
| Hypercalcemia | 0 | 0 | 1 | 0 |
| Hypophosphatemia | 0 | 4 | 3 | 1 |
| Hyperphosphatemia | 0 | 2 | 0 | 0 |
| Hypomagnesemia | 15 | 1 | 0 | 0 |
| Neurologic | ||||
| Headache | 8 | 2 | 3 | 0 |
| Seizure | 0 | 0 | 1 | 0 |
| Coagulation | ||||
| Increased PTT | 3 | 0 | 0 | 0 |
| Increased PT | 2 | 0 | 1 | 0 |
| Skin rash | 6 | 6 | 0 | 0 |
| Tumor lysis | 0 | 0 | 1 | 0 |
| No. of patients with event of common toxicity criteria . | ||||
|---|---|---|---|---|
| Event . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
| Gastrointestinal | ||||
| Emesis | 10 | 3 | 0 | 0 |
| Diarrhea | 14 | 2 | 0 | 0 |
| Mucositis | 7 | 3 | 0 | 0 |
| Liver functions | ||||
| Total bilirubin | 2 | 2 | 3 | 1 |
| Transaminases | 6 | 1 | 0 | 0 |
| Alkaline phosphatase | 6 | 0 | 0 | 0 |
| Cardiovascular | ||||
| Chest pain | 1 | 1 | 0 | 0 |
| Dizziness | 2 | 2 | 2 | 0 |
| Hypertension | 2 | 0 | 0 | 0 |
| Hypotension | 2 | 1 | 0 | 1 |
| Respiratory | ||||
| Hypoxia | 0 | 0 | 12 | 1 |
| Dyspnea | 0 | 3 | 10 | 0 |
| Renal | ||||
| Increased creatinine level | 3 | 1 | 0 | 0 |
| Fluid retention | 11 | 3 | 1 | 0 |
| Electrolytes | ||||
| Hyponatremia | 3 | 1 | 2 | 0 |
| Hypokalemia | 4 | 1 | 9 | 2 |
| Hypocalcemia | 4 | 10 | 2 | 1 |
| Hypercalcemia | 0 | 0 | 1 | 0 |
| Hypophosphatemia | 0 | 4 | 3 | 1 |
| Hyperphosphatemia | 0 | 2 | 0 | 0 |
| Hypomagnesemia | 15 | 1 | 0 | 0 |
| Neurologic | ||||
| Headache | 8 | 2 | 3 | 0 |
| Seizure | 0 | 0 | 1 | 0 |
| Coagulation | ||||
| Increased PTT | 3 | 0 | 0 | 0 |
| Increased PT | 2 | 0 | 1 | 0 |
| Skin rash | 6 | 6 | 0 | 0 |
| Tumor lysis | 0 | 0 | 1 | 0 |
PTT indicates partial thromboplastin time; and PT, prothrombin time.