First stem cell transplantation for Crohn disease
| Test/symptom . | Before transplantation . | After transplantation . | ||
|---|---|---|---|---|
| 2 mo . | 6 mo . | 15 mo . | ||
| Diarrhea | Average 25 times/d, sometimes bloody | None | None | None |
| Entry immune suppressive medications | Prednisone (22 mg/d), 6-MP | Prednisone 15 mg/d | Prednisone 7.5 mg/d* | Prednisone 5 mg/d (reduced at this visit to zero) |
| Opiates (dilaudid) | 3.0 mg/h | 2.3 mg/h | 1.1 mg/h | Oral methadone taper |
| Hemoglobin, mg/dL (normal, 12-15 mg/dL)* | 9.7 | 10.3 | 11.9 | 11.2 |
| CRP (normal, less than 2.5) | NA | 11 | 4.5 | 1.3 |
| Sedimentation rate (normal, less than 20) | NA | 49 | 42 | 33 |
| Albumin, g/dL (normal, 3.5-5.0 g/dL) | 3.3 | 3.7 | 4.1 | 3.3 |
| CDAI | 305 | 116 | 84 | 58 |
| Small-bowel x-ray | Terminal ileitis | Mild terminal ileum inflammation | Normal | Mild terminal ileum inflammation |
| Colonoscopy | Severe colitis | Mild colitis | Slight ulceration of ileocecal area | Pending |
| Colonoscopic biopsy | Severe colitis with granulomas | Mild colitis | Mild colitis | Pending |
| Test/symptom . | Before transplantation . | After transplantation . | ||
|---|---|---|---|---|
| 2 mo . | 6 mo . | 15 mo . | ||
| Diarrhea | Average 25 times/d, sometimes bloody | None | None | None |
| Entry immune suppressive medications | Prednisone (22 mg/d), 6-MP | Prednisone 15 mg/d | Prednisone 7.5 mg/d* | Prednisone 5 mg/d (reduced at this visit to zero) |
| Opiates (dilaudid) | 3.0 mg/h | 2.3 mg/h | 1.1 mg/h | Oral methadone taper |
| Hemoglobin, mg/dL (normal, 12-15 mg/dL)* | 9.7 | 10.3 | 11.9 | 11.2 |
| CRP (normal, less than 2.5) | NA | 11 | 4.5 | 1.3 |
| Sedimentation rate (normal, less than 20) | NA | 49 | 42 | 33 |
| Albumin, g/dL (normal, 3.5-5.0 g/dL) | 3.3 | 3.7 | 4.1 | 3.3 |
| CDAI | 305 | 116 | 84 | 58 |
| Small-bowel x-ray | Terminal ileitis | Mild terminal ileum inflammation | Normal | Mild terminal ileum inflammation |
| Colonoscopy | Severe colitis | Mild colitis | Slight ulceration of ileocecal area | Pending |
| Colonoscopic biopsy | Severe colitis with granulomas | Mild colitis | Mild colitis | Pending |
CRP indicates C reactive protein, CDAI, Crohn disease activity index (CDAI 250-400, severe disease; CDAI <100, remission); and NA, not available.
Patient is transfusion independent without erythropoietin.