Survival studies using log-rank test and Cox univariate analysis of the main variables studied
| Variables . | P,log-rank test . | Exp (B)-Cox . | 95.0% CI for Exp (B) . | |
|---|---|---|---|---|
| Low . | High . | |||
| Age older than 60 y | NS | — | — | — |
| Sex (F vs M) | NS | — | — | — |
| Stage III-IV | NS | — | — | — |
| IPI (4-5) | < .001 | 3.346 | 1.749 | 6.402 |
| Spleen | < .05 | 1.958 | 1.034 | 3.709 |
| Waldeyer | NS | — | — | — |
| Gastrointestinal | NS | — | — | — |
| Leukemic | NS | — | — | — |
| Tetraploidy | < .01 | 5.362 | 1.862 | 15.439 |
| Blastoid | NS | — | — | — |
| Architectural pattern | NS | — | — | — |
| Reactive GC | NS | — | — | — |
| CD5 | NS | — | — | — |
| IgD | NS | — | — | — |
| MIB-1 | < .05 | 2.055 | 1.0207 | 4.1390 |
| CD38 | .076 | 2.178 | 0.893 | 5.310 |
| p53 | NS | — | — | — |
| CD38-p53 | .062 | 2.411 | 0.921 | 6.310 |
| % ID less than 100 | NS | — | — | — |
| % ID less than 98 | NS | — | — | — |
| % ID less than 95 | NS | — | — | — |
| VHUSAGE | NS | — | — | — |
| VH3-23 | .066 | 2.47 | 0.952 | 6.407 |
| VH3-21 | .061 | 0.290 | 0.070 | 1.200 |
| VH4-34 | NS | — | — | — |
| VH4-59 | NS | — | — | — |
| VH3-21 orVH4-59 | < .05 | 0.366 | 0.144 | 0.930 |
| Variables . | P,log-rank test . | Exp (B)-Cox . | 95.0% CI for Exp (B) . | |
|---|---|---|---|---|
| Low . | High . | |||
| Age older than 60 y | NS | — | — | — |
| Sex (F vs M) | NS | — | — | — |
| Stage III-IV | NS | — | — | — |
| IPI (4-5) | < .001 | 3.346 | 1.749 | 6.402 |
| Spleen | < .05 | 1.958 | 1.034 | 3.709 |
| Waldeyer | NS | — | — | — |
| Gastrointestinal | NS | — | — | — |
| Leukemic | NS | — | — | — |
| Tetraploidy | < .01 | 5.362 | 1.862 | 15.439 |
| Blastoid | NS | — | — | — |
| Architectural pattern | NS | — | — | — |
| Reactive GC | NS | — | — | — |
| CD5 | NS | — | — | — |
| IgD | NS | — | — | — |
| MIB-1 | < .05 | 2.055 | 1.0207 | 4.1390 |
| CD38 | .076 | 2.178 | 0.893 | 5.310 |
| p53 | NS | — | — | — |
| CD38-p53 | .062 | 2.411 | 0.921 | 6.310 |
| % ID less than 100 | NS | — | — | — |
| % ID less than 98 | NS | — | — | — |
| % ID less than 95 | NS | — | — | — |
| VHUSAGE | NS | — | — | — |
| VH3-23 | .066 | 2.47 | 0.952 | 6.407 |
| VH3-21 | .061 | 0.290 | 0.070 | 1.200 |
| VH4-34 | NS | — | — | — |
| VH4-59 | NS | — | — | — |
| VH3-21 orVH4-59 | < .05 | 0.366 | 0.144 | 0.930 |
F indicates female; M, male; GC, germinal center; ID (identity), the homology of VH genes to the germline sequences; CI, confidence interval; NS, not significant; —, data not needed.