Altered populations of committed progenitors, Sca-1–null mice
| Progenitor . | Sca-1+/+ . | Sca-1−/− . |
|---|---|---|
| CFU-Es | 338.7 ± 27.3 | 367.6 ± 18.7 |
| BFU-Es | 39.4 ± 6.5 | 35.0 ± 9.6 |
| CFU-GEMMs | 26.1 ± 2.83-150 | 16.3 ± 2.23-150 |
| CFU-Mk's | 46.3 ± 5.63-150 | 19.7 ± 2.43-150 |
| CFU-GMs | 86.7 ± 8.93-150 | 127.1 ± 8.43-150 |
| CFU-Gs | 135.0 ± 4.6 | 126.3 ± 7.0 |
| CFU-Ms | 198.9 ± 6.13-150 | 220.4 ± 4.63-150 |
| Progenitor . | Sca-1+/+ . | Sca-1−/− . |
|---|---|---|
| CFU-Es | 338.7 ± 27.3 | 367.6 ± 18.7 |
| BFU-Es | 39.4 ± 6.5 | 35.0 ± 9.6 |
| CFU-GEMMs | 26.1 ± 2.83-150 | 16.3 ± 2.23-150 |
| CFU-Mk's | 46.3 ± 5.63-150 | 19.7 ± 2.43-150 |
| CFU-GMs | 86.7 ± 8.93-150 | 127.1 ± 8.43-150 |
| CFU-Gs | 135.0 ± 4.6 | 126.3 ± 7.0 |
| CFU-Ms | 198.9 ± 6.13-150 | 220.4 ± 4.63-150 |
Data are the average of 6 experiments using 3 animals from each genotype per experiment. Analysis was performed on 8- to 12-week-old mice for each genotype. Numbers are shown per 105 input bone marrow cells.
CFU-E indicates erythroid colony-forming unit; BFU-E, erythroid burst-forming unit; CFU-GEMM, granulocyte, erythroid, macrophage, megakaryocyte CFU; CFU-GM, granulocyte, macrophage CFU; CFU-M, macrophage CFU; CFU-G, granulocyte CFU; and CFU-Mk, megakaryocyte CFU.
Highly significant differences; P < .01.