Clinical data of 12 cases of extranodal MALT lymphoma characterized by t(14;18)(IGH;MALT1)
| Site . | Age/sex . | Stage3-150 . | Clinical history . | Additional sites involved . | Clinical course . | |
|---|---|---|---|---|---|---|
| At presentation . | During course . | |||||
| Liver | 72/F | Not staged | Colorectal adenocarcinoma; solitary hepatic nodule detected during follow-up | Not known | Not known | Died 1 month after liver biopsy |
| Liver | 61/F | EII1 | Rheumatoid arthritis; MALT lymphoma diagnosed at autopsy | Portal lymph nodes | None | Died of pulmonary embolism |
| Liver (multifocal) | 58/F | EI1 | None | None | None | Chemotherapy followed by resection, alive + 37 months (CR) |
| Liver | 62/F | EI1 | Breast cancer; solitary hepatic nodule detected during staging after modified mastectomy | None | None | Resection, tamoxifen; alive +9 months after resection (CR) |
| Lacrimal gland | 76/M | IV | Uneventful | Lacrimal gland (bilateral) | None | Chemotherapy; alive +32 months (CR) |
| Lacrimal gland | 81/M | EI | Uneventful | None | Not known | Chemotherapy, lost to follow-up |
| Orbit | 51/F | IV | Uneventful | Colon | None so far | Alive +4 months |
| Parotid gland | 50/F | EI1 | Sjögren syndrome; Hashimoto thyroiditis | None | None | Radiotherapy, alive +31 mos (CR) |
| Parotid gland | 36/F | IV | Sjögren syndrome | Parotid gland (contralateral) | None | Chemotherapy followed by radiation, alive +28 months (CR) |
| Skin, grouped lesions on left arm | 67/M | EI | Uneventful | None | None | Radiotherapy, alive +156 months (CR); died of unrelated cause |
| Skin, few lesions on arms and legs | 30/M | IV | Uneventful | None | None | Intralesional interferon, alive +60 months (CR) |
| Skin, more than 50 nodules on trunk | 44/M | IV | Uneventful | None | None | Rituximab, alive +16 months (CR) |
| Site . | Age/sex . | Stage3-150 . | Clinical history . | Additional sites involved . | Clinical course . | |
|---|---|---|---|---|---|---|
| At presentation . | During course . | |||||
| Liver | 72/F | Not staged | Colorectal adenocarcinoma; solitary hepatic nodule detected during follow-up | Not known | Not known | Died 1 month after liver biopsy |
| Liver | 61/F | EII1 | Rheumatoid arthritis; MALT lymphoma diagnosed at autopsy | Portal lymph nodes | None | Died of pulmonary embolism |
| Liver (multifocal) | 58/F | EI1 | None | None | None | Chemotherapy followed by resection, alive + 37 months (CR) |
| Liver | 62/F | EI1 | Breast cancer; solitary hepatic nodule detected during staging after modified mastectomy | None | None | Resection, tamoxifen; alive +9 months after resection (CR) |
| Lacrimal gland | 76/M | IV | Uneventful | Lacrimal gland (bilateral) | None | Chemotherapy; alive +32 months (CR) |
| Lacrimal gland | 81/M | EI | Uneventful | None | Not known | Chemotherapy, lost to follow-up |
| Orbit | 51/F | IV | Uneventful | Colon | None so far | Alive +4 months |
| Parotid gland | 50/F | EI1 | Sjögren syndrome; Hashimoto thyroiditis | None | None | Radiotherapy, alive +31 mos (CR) |
| Parotid gland | 36/F | IV | Sjögren syndrome | Parotid gland (contralateral) | None | Chemotherapy followed by radiation, alive +28 months (CR) |
| Skin, grouped lesions on left arm | 67/M | EI | Uneventful | None | None | Radiotherapy, alive +156 months (CR); died of unrelated cause |
| Skin, few lesions on arms and legs | 30/M | IV | Uneventful | None | None | Intralesional interferon, alive +60 months (CR) |
| Skin, more than 50 nodules on trunk | 44/M | IV | Uneventful | None | None | Rituximab, alive +16 months (CR) |
CR indicates complete remission.
Staging is given according to the Ann Arbor System, as modified by Radaszkiewicz et al for gastrointestinal lymphomas.25Standard staging procedures consisted of computed tomography scanning of thorax and abdomen; gastroscopy with mapping biopsies; endosonography of the upper gastrointestinal tract; enteroclysma; colonoscopy; bone marrow biopsy; imaging of salivary and lacrimal glands by means of magnetic resonance imaging or ultrasound; and ear, nose, and throat investigation. All lesions suggestive of lymphoma involvement were subjected to biopsy.