Univariate and multivariate Cox regression analysis of risk factors for overall survival
| Risk factor . | Univariate analysis . | P . | Multivariate analysis . | P . | ||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | HR . | 95% CI . | |||
| Age, continuous | 1.03 | 1.0-1.07 | .03 | — | — | NS |
| Stage III disease | 1.9 | 1.1-3.2 | .01 | — | — | NS |
| Stage B disease | 2.6 | 1.5-4.7 | .001 | 2.2 | 1.0-4.8 | .04 |
| Hb level less than or equal to 6.21 mM | 1.8 | 1.2-2.7 | .004 | 2.0 | 1.3-3.2 | .003 |
| β2-microglobulin greater than 3 mg/L | 2.3 | 1.5-3.5 | < .001 | 1.6 | 1.0-2.6 | .04 |
| LDH greater than ULN | 2.4 | 1.5-3.9 | < .001 | 2.1 | 1.2-3.5 | .007 |
| β2-microglobulin greater than 3 mg/L after VAD | 3.2 | 1.9-5.3 | < .001 | — | — | NI |
| Skeletal lesions (0 vs 1-2 vs ≥ 3) | 1.4 | 1.1-1.9 | .006 | 1.4 | 0.1-1.9 | .03 |
| Myeloablative treatment | 1.2 | 0.8-1.7 | .41 | — | — | NI |
| Risk factor . | Univariate analysis . | P . | Multivariate analysis . | P . | ||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | HR . | 95% CI . | |||
| Age, continuous | 1.03 | 1.0-1.07 | .03 | — | — | NS |
| Stage III disease | 1.9 | 1.1-3.2 | .01 | — | — | NS |
| Stage B disease | 2.6 | 1.5-4.7 | .001 | 2.2 | 1.0-4.8 | .04 |
| Hb level less than or equal to 6.21 mM | 1.8 | 1.2-2.7 | .004 | 2.0 | 1.3-3.2 | .003 |
| β2-microglobulin greater than 3 mg/L | 2.3 | 1.5-3.5 | < .001 | 1.6 | 1.0-2.6 | .04 |
| LDH greater than ULN | 2.4 | 1.5-3.9 | < .001 | 2.1 | 1.2-3.5 | .007 |
| β2-microglobulin greater than 3 mg/L after VAD | 3.2 | 1.9-5.3 | < .001 | — | — | NI |
| Skeletal lesions (0 vs 1-2 vs ≥ 3) | 1.4 | 1.1-1.9 | .006 | 1.4 | 0.1-1.9 | .03 |
| Myeloablative treatment | 1.2 | 0.8-1.7 | .41 | — | — | NI |
HR indicates hazard ratio; —, not applicable; NS, not significant; Hb, hemoglobin; NI, not included in multivariate analysis.