P falciparum degradation in CC cells
| Parasite line . | No. of degraded forms (%) . | No. of knobs/infected RBC, mean ± SD . | ||
|---|---|---|---|---|
| AA | CC | AA | CC | |
| 3D7 | 0/98 (0) | 52/99 (52) | ND | ND |
| Indochina | 1/64 (1.6) | 48/100 (48) | ND | ND |
| GB4 | 1/72 (1.4) | 63/112 (56) | ND | ND |
| ITG | 0/78 (0) | 46/108 (43) | 14.9 ± 2.7 | 5.1 ± 4.0 |
| 7G8 | 1/105 (1.0) | 97/206 (47) | 14.4 ± 7.1 | 3.9 ± 2.1 |
| TM284 | ND | 74/195 (38) | ND | 7.4 ± 6.2 |
| FMG | 0/105 (0) | 53/145 (36) | 28.8 ± 9.2 | 7.2 ± 2.9 |
| GB4 | 0/110 (0) | 108/198 (54) | 32.2 ± 8.7 | 17.4 ± 7.6 |
| Average | 0.57 ± 0.73 | 46.8 ± 7.3 | 22.6 ± 9.2 | 8.2 ± 5.3 |
| Parasite line . | No. of degraded forms (%) . | No. of knobs/infected RBC, mean ± SD . | ||
|---|---|---|---|---|
| AA | CC | AA | CC | |
| 3D7 | 0/98 (0) | 52/99 (52) | ND | ND |
| Indochina | 1/64 (1.6) | 48/100 (48) | ND | ND |
| GB4 | 1/72 (1.4) | 63/112 (56) | ND | ND |
| ITG | 0/78 (0) | 46/108 (43) | 14.9 ± 2.7 | 5.1 ± 4.0 |
| 7G8 | 1/105 (1.0) | 97/206 (47) | 14.4 ± 7.1 | 3.9 ± 2.1 |
| TM284 | ND | 74/195 (38) | ND | 7.4 ± 6.2 |
| FMG | 0/105 (0) | 53/145 (36) | 28.8 ± 9.2 | 7.2 ± 2.9 |
| GB4 | 0/110 (0) | 108/198 (54) | 32.2 ± 8.7 | 17.4 ± 7.6 |
| Average | 0.57 ± 0.73 | 46.8 ± 7.3 | 22.6 ± 9.2 | 8.2 ± 5.3 |
Parasite lines were cultured simultaneously in either AA or CC RBCs (2 donors) for 4 days. The number of healthy and degraded forms (rings, trophozoites) was then determined by electron microscopy. For each parasite culture in AA or CC cells, the number of knobs present on cross-sections of 9 trophozoite-infected RBCs was counted.
ND indicates not determined.