Table 2. Baseline factors tested for... | American Society of Hematology

Table 2.

Baseline factors tested for correlation with response to imatinib

Factor/category	No. of patients	No. of responses (%)	Univariate	Multivariate	Odds ratio	Score
Pretreatment
No	21	8 (38)	.944	—	—	—
Yes	23	9 (39)
Time diagnosis to BC^*
Less than 2 y	19	10 (53)	.139	—	—	—
2 y or older	26	8 (31)
Age^*
Younger than 60 y	33	14 (42)	.582	—	—	—
60 y or older	12	4 (33)
Sex
Male	20	6 (30)	.221	—	—	—
Female	25	12 (48)
Weight^*
Less than 70 kg	21	9 (43)	.714	—	—	—
70 kg or greater	24	9 (38)
Hepatomegaly
No	20	9 (45)	.540	—	—	—
Yes	25	9 (36)
Splenomegaly
No	19	7 (37)	.712	—	—	—
Yes	26	11 (42)
Hemoglobin level^*
Less than 100 g/L	20	6 (30)	.179	—	—	—
100 g/L or greater	24	12 (50)
WBC count^*
Less than 50 × 10⁹/L	32	13 (41)	.893	—	—	—
50 × 10⁹/L or greater	13	5 (38)
Platelet count^*
Less than 150 × 10⁹/L	27	6 (22)	.003^†	.015	21.6	1
150 × 10⁹/L or greater	18	12 (67)			1.0	0
Basophils in PB^*
Less than 10%	35	11 (31)	.053^†	NS	—	—
10% or greater	9	6 (67)
Blasts in PB^*
Less than 50%	28	15 (54)	.007^†	NS	—	—
50% or greater	16	2 (13)
Blasts in BM^*
Less than 50%	25	11 (44)	.573	—	—	—
50% or greater	17	6 (35)
Clonal evolution
No	22	10 (45)	.465	—	—	—
Yes	23	8 (35)

Factor/category	No. of patients	No. of responses (%)	Univariate	Multivariate	Odds ratio	Score
Pretreatment
No	21	8 (38)	.944	—	—	—
Yes	23	9 (39)
Time diagnosis to BC^*
Less than 2 y	19	10 (53)	.139	—	—	—
2 y or older	26	8 (31)
Age^*
Younger than 60 y	33	14 (42)	.582	—	—	—
60 y or older	12	4 (33)
Sex
Male	20	6 (30)	.221	—	—	—
Female	25	12 (48)
Weight^*
Less than 70 kg	21	9 (43)	.714	—	—	—
70 kg or greater	24	9 (38)
Hepatomegaly
No	20	9 (45)	.540	—	—	—
Yes	25	9 (36)
Splenomegaly
No	19	7 (37)	.712	—	—	—
Yes	26	11 (42)
Hemoglobin level^*
Less than 100 g/L	20	6 (30)	.179	—	—	—
100 g/L or greater	24	12 (50)
WBC count^*
Less than 50 × 10⁹/L	32	13 (41)	.893	—	—	—
50 × 10⁹/L or greater	13	5 (38)
Platelet count^*
Less than 150 × 10⁹/L	27	6 (22)	.003^†	.015	21.6	1
150 × 10⁹/L or greater	18	12 (67)			1.0	0
Basophils in PB^*
Less than 10%	35	11 (31)	.053^†	NS	—	—
10% or greater	9	6 (67)
Blasts in PB^*
Less than 50%	28	15 (54)	.007^†	NS	—	—
50% or greater	16	2 (13)
Blasts in BM^*
Less than 50%	25	11 (44)	.573	—	—	—
50% or greater	17	6 (35)
Clonal evolution
No	22	10 (45)	.465	—	—	—
Yes	23	8 (35)

WBC indicates white blood cell; NS, not significant; —, not significant in univariate analysis.

These parameters were also analyzed as continuous variables, without significant association with response.

Parameters that were significant at P < .1 in univariate analysis were included in the multivariate model.