Tumor-to–normal organ ratios using conventional RIT for131I-1F5 and 125I-BC8 at 24, 48, and 72 hours after the simultaneous injection of 131I-1F5 and125I-BC8 into athymic mice bearing Ramos tumors
| Organ . | . | Time, h . | ||
|---|---|---|---|---|
| 24 . | 48 . | 72 . | ||
| Blood | BC8 | 1.5 ± 0.5 | 1.3 ± 1.1 | 1.1 ± 0.7 |
| 1F5 | 0.44 ± 0.3 | 0.39 ± 0.3 | 0.31 ± 0.4 | |
| Kidney | BC8 | 3.4 ± 1.2 | 3.3 ± 1.6 | 3.6 ± 1.7 |
| 1F5 | 2.1 ± 0.8 | 1.6 ± 1.0 | 1.9 ± 1.3 | |
| Liver | BC8 | 4.7 ± 1.0 | 5.3 ± 1.3 | 6.5 ± 2.3 |
| 1F5 | 2.4 ± 0.6 | 2.0 ± 0.8 | 2.3 ± 1.2 | |
| Lung | BC8 | 4.0 ± 1.1 | 3.8 ± 1.4 | 3.5 ± 1.5 |
| 1F5 | 2.1 ± 0.5 | 2.0 ± 0.8 | 2.1 ± 1.1 | |
| Muscle | BC8 | 16.5 ± 1.7 | 14.3 ± 2.3 | 13.8 ± 0.9 |
| 1F5 | 8.7 ± 1.3 | 6.1 ± 2.0 | 4.4 ± 1.4 | |
| Small intestine | BC8 | 19.7 ± 2.6 | 16.9 ± 3.1 | 12.2 ± 2.2 |
| 1F5 | 9.8 ± 1.9 | 3.9 ± 1.3 | 5.2 ± 1.4 | |
| Colon | BC8 | 6.6 ± 2.3 | 4.2 ± 1.5 | 7.6 ± 1.9 |
| 1F5 | 2.0 ± 1.4 | 2.7 ± 1.4 | 4.6 ± 0.8 | |
| Spleen | BC8 | 3.5 ± 1.8 | 5.7 ± 2.4 | 5.5 ± 1.5 |
| 1F5 | 1.6 ± 0.7 | 1.7 ± 1.6 | 2.1 ± 0.5 | |
| Stomach | BC8 | 8.0 ± 2.2 | 6.6 ± 1.7 | 6.1 ± 1.4 |
| 1F5 | 3.6 ± 1.6 | 3.9 ± 1.4 | 2.4 ± 1.6 | |
| Marrow | BC8 | 4.0 ± 1.7 | 3.3 ± 2.0 | 5.2 ± 1.1 |
| 1F5 | 1.3 ± 0.6 | 1.1 ± 0.7 | 1.2 ± 0.3 | |
| Organ . | . | Time, h . | ||
|---|---|---|---|---|
| 24 . | 48 . | 72 . | ||
| Blood | BC8 | 1.5 ± 0.5 | 1.3 ± 1.1 | 1.1 ± 0.7 |
| 1F5 | 0.44 ± 0.3 | 0.39 ± 0.3 | 0.31 ± 0.4 | |
| Kidney | BC8 | 3.4 ± 1.2 | 3.3 ± 1.6 | 3.6 ± 1.7 |
| 1F5 | 2.1 ± 0.8 | 1.6 ± 1.0 | 1.9 ± 1.3 | |
| Liver | BC8 | 4.7 ± 1.0 | 5.3 ± 1.3 | 6.5 ± 2.3 |
| 1F5 | 2.4 ± 0.6 | 2.0 ± 0.8 | 2.3 ± 1.2 | |
| Lung | BC8 | 4.0 ± 1.1 | 3.8 ± 1.4 | 3.5 ± 1.5 |
| 1F5 | 2.1 ± 0.5 | 2.0 ± 0.8 | 2.1 ± 1.1 | |
| Muscle | BC8 | 16.5 ± 1.7 | 14.3 ± 2.3 | 13.8 ± 0.9 |
| 1F5 | 8.7 ± 1.3 | 6.1 ± 2.0 | 4.4 ± 1.4 | |
| Small intestine | BC8 | 19.7 ± 2.6 | 16.9 ± 3.1 | 12.2 ± 2.2 |
| 1F5 | 9.8 ± 1.9 | 3.9 ± 1.3 | 5.2 ± 1.4 | |
| Colon | BC8 | 6.6 ± 2.3 | 4.2 ± 1.5 | 7.6 ± 1.9 |
| 1F5 | 2.0 ± 1.4 | 2.7 ± 1.4 | 4.6 ± 0.8 | |
| Spleen | BC8 | 3.5 ± 1.8 | 5.7 ± 2.4 | 5.5 ± 1.5 |
| 1F5 | 1.6 ± 0.7 | 1.7 ± 1.6 | 2.1 ± 0.5 | |
| Stomach | BC8 | 8.0 ± 2.2 | 6.6 ± 1.7 | 6.1 ± 1.4 |
| 1F5 | 3.6 ± 1.6 | 3.9 ± 1.4 | 2.4 ± 1.6 | |
| Marrow | BC8 | 4.0 ± 1.7 | 3.3 ± 2.0 | 5.2 ± 1.1 |
| 1F5 | 1.3 ± 0.6 | 1.1 ± 0.7 | 1.2 ± 0.3 | |
Groups of 5 mice were used to generate mean values for each time point. Data were normalized for tissue weight and were corrected for radioactive decay.