Delineation of genomic imbalances associated with transformation in follicle center lymphoma by array CGH
| Chromosomal aberrations . | FCL cell lines . | Patient diagnosis . | Patients transformed . | Patients relapsed . | Total no. . | Minimal segment of genomic gain/loss . |
|---|---|---|---|---|---|---|
| −1p36 | 2 | 5 | 1 | 0 | 8 | RP11-51B4 (1p36.32) − RP11-82D16 (1p36.33) |
| +1q24 | 3 | 4 | 13-150 | 0 | 8 | RP11-184N12 (1q24) |
| +2p16 | 3 | 2 | 23-150 | 1 | 8 | GS-274P9 (2p16) |
| +3q27−q29 | 33-150 | 0 | 1 | 1 | 5 | CTD-2091K06 (3q27) − RP11-233N20 (3q29) |
| +4p12−pter | 0 | 0 | 1 | 1 | 2 | RP11-38M16 (4p12) − GS1-118B13 (4pter) |
| −4q21−q22 | 2 | 1 | 2 | 0 | 5 | RP11-115K14 (4q21.1) − RP11-36G19 (4q21.2) |
| +5p12p15 | 1 | 0 | 1 | 0 | 2 | RP11-9G14 (5p12) − RP11-227M19 (5p15.3) |
| −5q21−q23 | 0 | 0 | 1 | 0 | 1 | RP11-203J07 (5q21) − RP11-47L19 (5q23) |
| +6p12−p21 | 33-150 | 1 | 1 | 0 | 5 | RP3-445N2 (6p12.1) − RP11-40p17 (6p12.2 − 6p21.1) |
| −6q22−q24 | 2 | 4 | 1 | 0 | 7 | CTC-268N4 (6q22) − CTD2015J17 (6q24) |
| +7q11−q22 | 83-150 | 0 | 1 | 0 | 9 | RP11-96O16 (7q11.2) − CTC-30512 (7q22) |
| +9p23 | 33-150 | 0 | 1 | 0 | 4 | RP11-117J18 (9p23) |
| +9q13−q31 | 1 | 0 | 1 | 0 | 2 | CTD-2029120 (9q13) − RP11-5K11 (9q31) |
| −9q31−qter | 1 | 0 | 1 | 0 | 2 | RP11-80F13 (9q31) − GS1-135I17 (9qter) |
| +10 | 3 | 0 | 1 | 0 | 4 | GS1-23B11 (10pter) − GS1-261B16 (10qter) |
| −11q24−q25 | 2 | 0 | 1 | 0 | 3 | RP11-145L11 (11q23 − 11q24) − RP1-26N8 (11qter) |
| +12pter−12q12 | 6 | 0 | 2 | 0 | 8 | RP11-110K11 (12p13.3) − RP11-29G23 (12q12) |
| −13q13−q21 | 1 | 2 | 3 | 0 | 6 | RP11-14A4 (13q13); RP11-58D13 (13q14); RP11-234M13 (13q21.1); RP11-205J24 (13q21) |
| −15q23 | 1 | 0 | 1 | 0 | 2 | CTD-2022G15 (15q23) |
| +16 | 2 | 1 | 1 | 0 | 4 | CTD-2371A5 (16pter) − RP11-7D23 (16qter) |
| −17p12−pter | 1 | 2 | 1 | 0 | 4 | RPC-169E11 (17p12) − GS1-68F18 (17pter) |
| +17q21 | 1 | 4 | 2 | 1 | 8 | CTB-305D20 (17q21) |
| +18q21 | 63-150 | 7 | 2 | 0 | 15 | GS-385N22 (18q21.3) − RP11-12J12 (18q22) |
| +20pter−20qter | 3 | 0 | 1 | 0 | 4 | RP11-82O2 (20pter) − RP11-81F12 (20qter) |
| +21q11−qter | 1 | 0 | 1 | 0 | 2 | RP11-96H21 (21q21) − RP11-135B17 (21qter) |
| +Xq11−q21 | 3 | 0 | 1 | 0 | 4 | RP11-177A04 (Xq13) |
| +Xq25−q26 | 3 | 0 | 2 | 0 | 5 | CTD-2015J18 (Xq25) − RP11-97N5 (Xq26) |
| Chromosomal aberrations . | FCL cell lines . | Patient diagnosis . | Patients transformed . | Patients relapsed . | Total no. . | Minimal segment of genomic gain/loss . |
|---|---|---|---|---|---|---|
| −1p36 | 2 | 5 | 1 | 0 | 8 | RP11-51B4 (1p36.32) − RP11-82D16 (1p36.33) |
| +1q24 | 3 | 4 | 13-150 | 0 | 8 | RP11-184N12 (1q24) |
| +2p16 | 3 | 2 | 23-150 | 1 | 8 | GS-274P9 (2p16) |
| +3q27−q29 | 33-150 | 0 | 1 | 1 | 5 | CTD-2091K06 (3q27) − RP11-233N20 (3q29) |
| +4p12−pter | 0 | 0 | 1 | 1 | 2 | RP11-38M16 (4p12) − GS1-118B13 (4pter) |
| −4q21−q22 | 2 | 1 | 2 | 0 | 5 | RP11-115K14 (4q21.1) − RP11-36G19 (4q21.2) |
| +5p12p15 | 1 | 0 | 1 | 0 | 2 | RP11-9G14 (5p12) − RP11-227M19 (5p15.3) |
| −5q21−q23 | 0 | 0 | 1 | 0 | 1 | RP11-203J07 (5q21) − RP11-47L19 (5q23) |
| +6p12−p21 | 33-150 | 1 | 1 | 0 | 5 | RP3-445N2 (6p12.1) − RP11-40p17 (6p12.2 − 6p21.1) |
| −6q22−q24 | 2 | 4 | 1 | 0 | 7 | CTC-268N4 (6q22) − CTD2015J17 (6q24) |
| +7q11−q22 | 83-150 | 0 | 1 | 0 | 9 | RP11-96O16 (7q11.2) − CTC-30512 (7q22) |
| +9p23 | 33-150 | 0 | 1 | 0 | 4 | RP11-117J18 (9p23) |
| +9q13−q31 | 1 | 0 | 1 | 0 | 2 | CTD-2029120 (9q13) − RP11-5K11 (9q31) |
| −9q31−qter | 1 | 0 | 1 | 0 | 2 | RP11-80F13 (9q31) − GS1-135I17 (9qter) |
| +10 | 3 | 0 | 1 | 0 | 4 | GS1-23B11 (10pter) − GS1-261B16 (10qter) |
| −11q24−q25 | 2 | 0 | 1 | 0 | 3 | RP11-145L11 (11q23 − 11q24) − RP1-26N8 (11qter) |
| +12pter−12q12 | 6 | 0 | 2 | 0 | 8 | RP11-110K11 (12p13.3) − RP11-29G23 (12q12) |
| −13q13−q21 | 1 | 2 | 3 | 0 | 6 | RP11-14A4 (13q13); RP11-58D13 (13q14); RP11-234M13 (13q21.1); RP11-205J24 (13q21) |
| −15q23 | 1 | 0 | 1 | 0 | 2 | CTD-2022G15 (15q23) |
| +16 | 2 | 1 | 1 | 0 | 4 | CTD-2371A5 (16pter) − RP11-7D23 (16qter) |
| −17p12−pter | 1 | 2 | 1 | 0 | 4 | RPC-169E11 (17p12) − GS1-68F18 (17pter) |
| +17q21 | 1 | 4 | 2 | 1 | 8 | CTB-305D20 (17q21) |
| +18q21 | 63-150 | 7 | 2 | 0 | 15 | GS-385N22 (18q21.3) − RP11-12J12 (18q22) |
| +20pter−20qter | 3 | 0 | 1 | 0 | 4 | RP11-82O2 (20pter) − RP11-81F12 (20qter) |
| +21q11−qter | 1 | 0 | 1 | 0 | 2 | RP11-96H21 (21q21) − RP11-135B17 (21qter) |
| +Xq11−q21 | 3 | 0 | 1 | 0 | 4 | RP11-177A04 (Xq13) |
| +Xq25−q26 | 3 | 0 | 2 | 0 | 5 | CTD-2015J18 (Xq25) − RP11-97N5 (Xq26) |
Includes one gene amplification event.