List of genes with deregulated expression located at the transformation-associated chromosomal aberrations
| Case . | Chromosome . | Genes . |
|---|---|---|
| IL105 | −5q21q23 | D5S346, GPX3, ADRA1B |
| +17q11qter | SCYA4, KIAA0356, ITGB3, TK1, H3F3B, RPL27, SMT3H2, ACTG1, KPNA2, NME1, NME2, MSF, KPNA2, GCN5L2, HN1, PSCD1, CD79B, ICAM2, CLTC, RARA, SCYA16, ACLY, IGFBP4, STAT3, TUBG2, GCN5L2, RPL27, TK1, SCYA3L1, NXPH3, EAP30, SPAG9, SFRS1, SUPT4H1, PRKAR1A, SMARCD2, MGC10986, BIRC5, CSNK1D, SFRS2, SMT3H2, ALY | |
| IL114 | +1q24 | RER1, TAGLN2, SELL, CREG, DKFZP564B167, CACYBP |
| +2p16 | PEX13, MDH1, XPO1 | |
| −4 | FLJ20706, 4-150FLJ20280 | |
| +5p12p15 | PDCD6, CCT5, NNT, RAD1, SEMA5A, FLJ20303, TRIP13 | |
| −6q11qter | ME1, TTK, BACH2, DKFZP564B0769, KIAA0776, FOXO3A, NMBR, SMPD2, MAP3K5, VNN2, HIVEP2, KIAA1209, RNASE6PL | |
| +7 | POR, FZD9, YWHAG, OGDH, SLC25A13, HNRPA2B1, MCM7, MDH2, KOC1, POLD2, PSMA2, PURB, AHR, GARS, ACTB, ARL4, DKFZP434J154, NUDT1, RAC1, RPA3, HRI, JTV1, KDELR2, FLJ20397, EIF3S9, RALA, KIAA0442, LOC51142, CCT6A, CRIP1, CYP51, PLOD3, GNB2, PMS2L8, STAG3, VGF, CUTL1, KIAA0632, COL1A2, PSMC2, EBNA-2 co-activator, IMPDH1, DLD, ATP6S14, KIAA1170, AKR1B1, EZH2, RHEB2, FLJ20311 | |
| +9p23p24 | ||
| +9q13q31 | TXN, SEC61B, FPGS, PRKACG, BTEB1, CDC20, CTSL, CKS2, C90RF3, CKS2, SEC61B, FLJ20287, TXN | |
| −9q31qter | ORM1, TNFSF8, HSPA5, ASS, COL5A1 | |
| +10 | CHUK, PP, DDX21, ATP5C1, MXI1, VIM, PRDX3, ACF, MGMT, PGAM1, VDAC2, UROS, ERP70, SSH3BP1, TCF8, CREM, COPEB, GDI2, PFKP, PHYH, LOC51008, RET, HNRPF, MBL2, JDP1, CDC2, ANXA7, ZWINT, HK1, PRG1, VCL, PPIF, ANXA11, DLG5, KIAA0261, MPHOSPH1, PLAU, GBF1, ACTR1A, RGS10, ABLIM, MK167, OAT, ECHS1, ADAM8 | |
| −11q11qter | GSTP1, POU2AF1, MS4A7, HTATIP, EMK1, MS4A2, SYT7, ZFPL1, CD6, RASGRP2, FOLR1, KIAA0102, ACTN3, FLJ20189, SCDGF-B, ATM, CASP1, INPPL1, MLL, UBE4A, CBL | |
| +12pter-q14 | PA2G4, LRMP, REA, TUBA3, K-ALPHA-1, LDHB, GAPD, TPI1, DDX11, CS, FLJ22028, KIAA0528, ARHGD1B, FOXM1, MLF2, C1S, PXR1, GPR92, COPS7A, FKBP4, CD69, ATP5B, CD4, CNTN1, SHMT2, PRKAG1, NR4A1, CDK2, HSU47926, MGC5576, HEM1, HNRPA1, MYL6, ATP5G2, EIF4B, FLJ11773, DDIT3, MARS, HSPD1, HSPC228, SAS, RAP1B, CDK4, NEDD1, NR2C1, FLJ11021, ZNF10 | |
| −13q11qter | GJB2, SACS, YDD19, ALOX5AP, HMG1, CG005, D13S106E,4-150 ELF1, AKAP11, SLC25A15, RFP2, FOXO1A, FLJ21562, FBXL3A, GPR18, EFNB2, FLJ10154, ATP11A | |
| −15q23 | RCN2, FBXO22 | |
| +16 | GLG1, AARS, ALDOA, EIF3S8, RPL13 KIAA0251, KNSL4, STX4A, SULT1A3, ITGAL, MAX, ITGAX, UQCRC2, SULT1A1, PHKG2, SULT1A2, PLK, PPP4C, ARL6IP, MHC2TA, TNFRSF17, GSPT1, HIRIP3, NK4, PKMYT1, POLR3K, PRSS22, RNPS1, SEPX1, STUB1, CCNF, BOM045, HMOX2, HMT-1, PMM2, DREV1, SIAH1, SCYD1, CPSF5, GOT2, KIAA0095, E2F4, ATP6D, PP15, RCD-8, CBFB, FLJ13725, FLJ10305, LOC51659, MAP1A/1BLC3, PCOLN3, SLC7A5, TUBB4, CDT1, SLC7A5 | |
| −17p12pter | SERPINF1, DOC2B | |
| +18q11qter | FLJ21172, PMAIP1,4-150 PIK3C3, MADH2, TNFRSF11A | |
| +20 | ADA, PCNA, KIAA1219, CDC25B, GNAS1, PSMA7, MYBL2, AHCY, PTPRA, INSM1, FKBP1A, SNRPB, MAPRE1, E2F1, GSS, BCL2L1, RALY, MMP9, ITGB4BP, PLTP, TOP1, TNFRSF5, B4GALT5, STK15 | |
| +Xq21qter | TMSB4X, SLC25A5, HPRT1, PIM2, ZNF41, DSIPI, SAT, FLJ20811, UBE2A, HDGF, CXORF1, CLIC2, ARD1, ARHGAP4, CETN2, DXS1357E | |
| IL116 | +2p16 | KIAA1048 |
| +6p11pter | LTB, GABBR1, HLA-A, MDFI, PSMB9, HLA-DRB1, RPA40, GLO1 | |
| IL120 | −1p36 | LAP18, RPL11, PABPC4, AKR7A2, HUMHOXY1, CDC42, SMP1, HP1-BP74, EIF4G3, SDHB, NPPA, FGR, NBL1, ENO1, RER1 |
| −13q14 | LCP1, D13S106E,4-150 TSC22, CHCIL | |
| +17q11qter | ||
| IL121 | +18pter−q21.3 | PMAIP14-150 |
| +X | ZNF41, PIM2, SAT, IL13RA1 | |
| IL123 | +21q11qter | HMG14, ERG, DKFZP434C128 |
| IL124 | +4p11pter | TEC, ACOX3, FLJ20280, HMGE, SH3BP2, WHSC1 |
| −4q21qter | HNRPDL, FLJ20706,4-150 NFKB1, FLJ20647, CASP3, FLJ11200 | |
| +12 | ||
| IL126 | +3q12qter | GYG, PXR2b |
| −13q21.1 |
| Case . | Chromosome . | Genes . |
|---|---|---|
| IL105 | −5q21q23 | D5S346, GPX3, ADRA1B |
| +17q11qter | SCYA4, KIAA0356, ITGB3, TK1, H3F3B, RPL27, SMT3H2, ACTG1, KPNA2, NME1, NME2, MSF, KPNA2, GCN5L2, HN1, PSCD1, CD79B, ICAM2, CLTC, RARA, SCYA16, ACLY, IGFBP4, STAT3, TUBG2, GCN5L2, RPL27, TK1, SCYA3L1, NXPH3, EAP30, SPAG9, SFRS1, SUPT4H1, PRKAR1A, SMARCD2, MGC10986, BIRC5, CSNK1D, SFRS2, SMT3H2, ALY | |
| IL114 | +1q24 | RER1, TAGLN2, SELL, CREG, DKFZP564B167, CACYBP |
| +2p16 | PEX13, MDH1, XPO1 | |
| −4 | FLJ20706, 4-150FLJ20280 | |
| +5p12p15 | PDCD6, CCT5, NNT, RAD1, SEMA5A, FLJ20303, TRIP13 | |
| −6q11qter | ME1, TTK, BACH2, DKFZP564B0769, KIAA0776, FOXO3A, NMBR, SMPD2, MAP3K5, VNN2, HIVEP2, KIAA1209, RNASE6PL | |
| +7 | POR, FZD9, YWHAG, OGDH, SLC25A13, HNRPA2B1, MCM7, MDH2, KOC1, POLD2, PSMA2, PURB, AHR, GARS, ACTB, ARL4, DKFZP434J154, NUDT1, RAC1, RPA3, HRI, JTV1, KDELR2, FLJ20397, EIF3S9, RALA, KIAA0442, LOC51142, CCT6A, CRIP1, CYP51, PLOD3, GNB2, PMS2L8, STAG3, VGF, CUTL1, KIAA0632, COL1A2, PSMC2, EBNA-2 co-activator, IMPDH1, DLD, ATP6S14, KIAA1170, AKR1B1, EZH2, RHEB2, FLJ20311 | |
| +9p23p24 | ||
| +9q13q31 | TXN, SEC61B, FPGS, PRKACG, BTEB1, CDC20, CTSL, CKS2, C90RF3, CKS2, SEC61B, FLJ20287, TXN | |
| −9q31qter | ORM1, TNFSF8, HSPA5, ASS, COL5A1 | |
| +10 | CHUK, PP, DDX21, ATP5C1, MXI1, VIM, PRDX3, ACF, MGMT, PGAM1, VDAC2, UROS, ERP70, SSH3BP1, TCF8, CREM, COPEB, GDI2, PFKP, PHYH, LOC51008, RET, HNRPF, MBL2, JDP1, CDC2, ANXA7, ZWINT, HK1, PRG1, VCL, PPIF, ANXA11, DLG5, KIAA0261, MPHOSPH1, PLAU, GBF1, ACTR1A, RGS10, ABLIM, MK167, OAT, ECHS1, ADAM8 | |
| −11q11qter | GSTP1, POU2AF1, MS4A7, HTATIP, EMK1, MS4A2, SYT7, ZFPL1, CD6, RASGRP2, FOLR1, KIAA0102, ACTN3, FLJ20189, SCDGF-B, ATM, CASP1, INPPL1, MLL, UBE4A, CBL | |
| +12pter-q14 | PA2G4, LRMP, REA, TUBA3, K-ALPHA-1, LDHB, GAPD, TPI1, DDX11, CS, FLJ22028, KIAA0528, ARHGD1B, FOXM1, MLF2, C1S, PXR1, GPR92, COPS7A, FKBP4, CD69, ATP5B, CD4, CNTN1, SHMT2, PRKAG1, NR4A1, CDK2, HSU47926, MGC5576, HEM1, HNRPA1, MYL6, ATP5G2, EIF4B, FLJ11773, DDIT3, MARS, HSPD1, HSPC228, SAS, RAP1B, CDK4, NEDD1, NR2C1, FLJ11021, ZNF10 | |
| −13q11qter | GJB2, SACS, YDD19, ALOX5AP, HMG1, CG005, D13S106E,4-150 ELF1, AKAP11, SLC25A15, RFP2, FOXO1A, FLJ21562, FBXL3A, GPR18, EFNB2, FLJ10154, ATP11A | |
| −15q23 | RCN2, FBXO22 | |
| +16 | GLG1, AARS, ALDOA, EIF3S8, RPL13 KIAA0251, KNSL4, STX4A, SULT1A3, ITGAL, MAX, ITGAX, UQCRC2, SULT1A1, PHKG2, SULT1A2, PLK, PPP4C, ARL6IP, MHC2TA, TNFRSF17, GSPT1, HIRIP3, NK4, PKMYT1, POLR3K, PRSS22, RNPS1, SEPX1, STUB1, CCNF, BOM045, HMOX2, HMT-1, PMM2, DREV1, SIAH1, SCYD1, CPSF5, GOT2, KIAA0095, E2F4, ATP6D, PP15, RCD-8, CBFB, FLJ13725, FLJ10305, LOC51659, MAP1A/1BLC3, PCOLN3, SLC7A5, TUBB4, CDT1, SLC7A5 | |
| −17p12pter | SERPINF1, DOC2B | |
| +18q11qter | FLJ21172, PMAIP1,4-150 PIK3C3, MADH2, TNFRSF11A | |
| +20 | ADA, PCNA, KIAA1219, CDC25B, GNAS1, PSMA7, MYBL2, AHCY, PTPRA, INSM1, FKBP1A, SNRPB, MAPRE1, E2F1, GSS, BCL2L1, RALY, MMP9, ITGB4BP, PLTP, TOP1, TNFRSF5, B4GALT5, STK15 | |
| +Xq21qter | TMSB4X, SLC25A5, HPRT1, PIM2, ZNF41, DSIPI, SAT, FLJ20811, UBE2A, HDGF, CXORF1, CLIC2, ARD1, ARHGAP4, CETN2, DXS1357E | |
| IL116 | +2p16 | KIAA1048 |
| +6p11pter | LTB, GABBR1, HLA-A, MDFI, PSMB9, HLA-DRB1, RPA40, GLO1 | |
| IL120 | −1p36 | LAP18, RPL11, PABPC4, AKR7A2, HUMHOXY1, CDC42, SMP1, HP1-BP74, EIF4G3, SDHB, NPPA, FGR, NBL1, ENO1, RER1 |
| −13q14 | LCP1, D13S106E,4-150 TSC22, CHCIL | |
| +17q11qter | ||
| IL121 | +18pter−q21.3 | PMAIP14-150 |
| +X | ZNF41, PIM2, SAT, IL13RA1 | |
| IL123 | +21q11qter | HMG14, ERG, DKFZP434C128 |
| IL124 | +4p11pter | TEC, ACOX3, FLJ20280, HMGE, SH3BP2, WHSC1 |
| −4q21qter | HNRPDL, FLJ20706,4-150 NFKB1, FLJ20647, CASP3, FLJ11200 | |
| +12 | ||
| IL126 | +3q12qter | GYG, PXR2b |
| −13q21.1 |
Genes showing at least 2-fold difference in expression upon transformation. In cases with genomic gain/amplification, overexpressed genes were considered. In cases with genomic deletion, genes with decreased expression are shown.
Genes whose expression changed in two cases.