Table 3. Clinical effects of THAL-PRED... | American Society of Hematology

Table 3.

Clinical effects of THAL-PRED on 21 patients with MMM

Demographics								THAL-PRED effects									Responses
Patient	Age	Sex	MMM type	Cell	RF	OS	AG	Karyotype	Hb start	Hb max	PLT start	PLT max	Spleen start	Spleen min	CD34⁺ at start	CD34⁺ at 3 mo	Anemia	Platelet	Spleen
1	72	F	AMM	30	2.5	0	4	Normal	9.7^3-150	10.7^3-150	24	35	9	9	851	1288	N	N	N
2	55	M	PPMM	95	1.5	0	4	(18p+)	12.9	15.2	303	477	15	13	24	17	Y	NA	N
3	78	M	AMM	70	2.0	0	4	Normal	8.4	11.3	154	389	22	13	32	41	Y	NA	Y
4	55	M	AMM	80	2.5	0	3	Normal	9.6^3-150	10.8	127	214	10	6	14	12	Y	NA	N
5	73	F	AMM	5	3.0	0	3	t(1;10)	7.9	13	95	228	5	0	104	13	Y	Y	Y
6	66	M	PTMM	30	2.5	0	3	t(3;4)	7.2^3-150	8.7^3-150	157	323	12	12	447	4437	N	NA	N
7	74	M	AMM	50	2.0	0	4	Normal	9^3-150	9.8	448	890	20	17	63	371	Y	NA	N
8	64	M	AMM	95	1.0	0	4	(+21)	7.5^3-150	9.6^3-150	138	167	20	14	1211	3913	N	NA	N
9	60	M	AMM	80	2.0	2	4	(13q−)	11	11.1	32	37	26	26	43	744	N	N	N
10	73	M	AMM	15	2.0	2	3	t(1;7)	9.8	11.5	38	79	8	8	1891	NA	N	Y	N
11	64	F	PPMM	30	2.0	2	3	(20q−)	10.9	13	186	391	8	4	84	100	Y	NA	Y
12	69	M	AMM	40	1.5	0	4	Normal	8.3^3-150	10.4	32	96	0	0	3	3	Y	Y	N
13	74	M	AMM	40	2.0	0	4	(20q−)	8.3^3-150	9.7^3-150	37	101	20	18	15	13	Y	Y	N
14	46	M	AMM	30	1.5	3	3	Normal	9	10.6	275	540	14	6	206	132	Y	NA	Y
15	49	M	MMM	95	2.0	0	4	Normal	8.3	11	192	390	15	11	119	73	Y	NA	N
16	66	F	AMM	5	2.0	0	3	Complex	8.8^3-150	11.2	74	192	0	0	83	1010	Y	Y	N
17	62	M	AMM	5	2.5	0	3	NA	9.4^3-150	11.2^3-150	162	316	8	8	354	427	Y	NA	N
18	43	M	AMM	30	2.0	3	4	Normal	10.7	11.7	179	415	18	15	273	271	N	NA	N
19	75	M	PTMM	70	2.0	1	4	(20q−)	8.3	10.7	231	328	20	17	42	61	N	NA	N
20	63	M	PPMM	80	1.5	0	4	Normal	12	13.4	446	569	25	25	151	166	N	NA	N
21	73	F	PTMM	5	2.0	0	2	Normal	8.6^3-150	10.4^3-150	23	44	6	5	103	28	Y	Y	N

Demographics								THAL-PRED effects									Responses
Patient	Age	Sex	MMM type	Cell	RF	OS	AG	Karyotype	Hb start	Hb max	PLT start	PLT max	Spleen start	Spleen min	CD34⁺ at start	CD34⁺ at 3 mo	Anemia	Platelet	Spleen
1	72	F	AMM	30	2.5	0	4	Normal	9.7^3-150	10.7^3-150	24	35	9	9	851	1288	N	N	N
2	55	M	PPMM	95	1.5	0	4	(18p+)	12.9	15.2	303	477	15	13	24	17	Y	NA	N
3	78	M	AMM	70	2.0	0	4	Normal	8.4	11.3	154	389	22	13	32	41	Y	NA	Y
4	55	M	AMM	80	2.5	0	3	Normal	9.6^3-150	10.8	127	214	10	6	14	12	Y	NA	N
5	73	F	AMM	5	3.0	0	3	t(1;10)	7.9	13	95	228	5	0	104	13	Y	Y	Y
6	66	M	PTMM	30	2.5	0	3	t(3;4)	7.2^3-150	8.7^3-150	157	323	12	12	447	4437	N	NA	N
7	74	M	AMM	50	2.0	0	4	Normal	9^3-150	9.8	448	890	20	17	63	371	Y	NA	N
8	64	M	AMM	95	1.0	0	4	(+21)	7.5^3-150	9.6^3-150	138	167	20	14	1211	3913	N	NA	N
9	60	M	AMM	80	2.0	2	4	(13q−)	11	11.1	32	37	26	26	43	744	N	N	N
10	73	M	AMM	15	2.0	2	3	t(1;7)	9.8	11.5	38	79	8	8	1891	NA	N	Y	N
11	64	F	PPMM	30	2.0	2	3	(20q−)	10.9	13	186	391	8	4	84	100	Y	NA	Y
12	69	M	AMM	40	1.5	0	4	Normal	8.3^3-150	10.4	32	96	0	0	3	3	Y	Y	N
13	74	M	AMM	40	2.0	0	4	(20q−)	8.3^3-150	9.7^3-150	37	101	20	18	15	13	Y	Y	N
14	46	M	AMM	30	1.5	3	3	Normal	9	10.6	275	540	14	6	206	132	Y	NA	Y
15	49	M	MMM	95	2.0	0	4	Normal	8.3	11	192	390	15	11	119	73	Y	NA	N
16	66	F	AMM	5	2.0	0	3	Complex	8.8^3-150	11.2	74	192	0	0	83	1010	Y	Y	N
17	62	M	AMM	5	2.5	0	3	NA	9.4^3-150	11.2^3-150	162	316	8	8	354	427	Y	NA	N
18	43	M	AMM	30	2.0	3	4	Normal	10.7	11.7	179	415	18	15	273	271	N	NA	N
19	75	M	PTMM	70	2.0	1	4	(20q−)	8.3	10.7	231	328	20	17	42	61	N	NA	N
20	63	M	PPMM	80	1.5	0	4	Normal	12	13.4	446	569	25	25	151	166	N	NA	N
21	73	F	PTMM	5	2.0	0	2	Normal	8.6^3-150	10.4^3-150	23	44	6	5	103	28	Y	Y	N

Age indicates patient's age at registration; cell, bone marrow cellularity; RF, reticulin fibrosis grade 0-4; OS, osteosclerosis grade 0-4; AG, angiogenesis grade 1-4; Karyotype, G-banded karyotype on 20 metaphases from bone marrow aspirate at time of registration; Hb, hemoglobin in g/dL; PLT, platelet count (× 10⁹/L); Spleen, spleen size (cm below the left costal margin by palpation); CD34⁺, CD34⁺ cell enumeration in peripheral blood by flow cytometry (cells/μL); Y, yes; N, no; NA, not applicable.

F3-150

Dependent on erythrocyte transfusions.

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