Comparison of proviral load, frequency and degeneracy of HTLV-1 Tax 11-19-specific T cells, and epitope variant among 3 patients with HAM/TSP
| Patient no. . | Proviral load, copy/104 PBMCs . | Frequency, % in CD8+cells . | Degeneracy,* % . | Epitope variant,† % . |
|---|---|---|---|---|
| 31 | 606.0 ± 64.0‡ | 14.0 ± 5.1§ | 25.4 ± 18.61-155 | 3.4 ± 2.5 |
| 38 | 1823.0 ± 303.1¶ | 2.7 ± 0.5 | 7.5 ± 3.8# | 8.8 ± 10.5 |
| 48 | 306.5 ± 240.5 | 2.7 ± 2.0 | 52.3 ± 30.1 | 4.8 ± 2.3 |
| Patient no. . | Proviral load, copy/104 PBMCs . | Frequency, % in CD8+cells . | Degeneracy,* % . | Epitope variant,† % . |
|---|---|---|---|---|
| 31 | 606.0 ± 64.0‡ | 14.0 ± 5.1§ | 25.4 ± 18.61-155 | 3.4 ± 2.5 |
| 38 | 1823.0 ± 303.1¶ | 2.7 ± 0.5 | 7.5 ± 3.8# | 8.8 ± 10.5 |
| 48 | 306.5 ± 240.5 | 2.7 ± 2.0 | 52.3 ± 30.1 | 4.8 ± 2.3 |
The numbers indicate mean ± SD.
Degeneracy of HTLV-1 Tax 11-19-specific T cells is accessed by the average of relative T-cell responses to APLs during the time course.
Percentage of epitope variant is given by the division of the number of variants by the number of clones sequenced in each patient.
P, as estimated by the Mann-Whitney U test, is significantly different between patients no. 31 and no. 38 (‡P < .0001), no. 31 and no. 38 (§P< .0006), no. 31 and no. 48 (§P < .0006), no. 31 and no. 38 (
P < 0.0005), no. 31 and no. 48 (∥P < .0001), no. 38 and no. 48 (¶P < .0001), and no. 38 and no. 48 (#P < .0001).